Universal Versus Targeted Screening for Lynch Syndrome: Comparing Ascertainment and Costs Based on Clinical Experience

Background Strategies to screen colorectal cancers (CRCs) for Lynch syndrome are evolving rapidly; the optimal strategy remains uncertain. Aim We compared targeted versus universal screening of CRCs for Lynch syndrome. Methods In 2010–2011, we employed targeted screening (age

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Veröffentlicht in:	Digestive diseases and sciences 2016-10, Vol.61 (10), p.2887-2895
Hauptverfasser:	Erten, Mujde Z., Fernandez, Luca P., Ng, Hank K., McKinnon, Wendy C., Heald, Brandie, Koliba, Christopher J., Greenblatt, Marc S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Biochemistry Cancer Colonoscopy - economics Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - economics Colorectal Neoplasms - genetics Colorectal Neoplasms - prevention & control Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - economics Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Comparative analysis Diagnosis DNA Mismatch Repair - genetics DNA-Binding Proteins - genetics Early Detection of Cancer Economic aspects Gastroenterology Gene mutations Genetic screening Genetic Testing - economics Germ-Line Mutation Health Care Costs Hepatology Humans Immunohistochemistry Immunohistochemistry - economics Mass Screening - economics Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Mismatch Repair Endonuclease PMS2 - genetics MutL Protein Homolog 1 - genetics MutS Homolog 2 Protein - genetics Oncology Original Article Patient Selection Pneumoviridae Proteins Systems Analysis Transplant Surgery United States
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Beschreibung
Zusammenfassung:	Background Strategies to screen colorectal cancers (CRCs) for Lynch syndrome are evolving rapidly; the optimal strategy remains uncertain. Aim We compared targeted versus universal screening of CRCs for Lynch syndrome. Methods In 2010–2011, we employed targeted screening (age
ISSN:	0163-2116 1573-2568
DOI:	10.1007/s10620-016-4218-y