Dysregulation of MicroRNA-34a Expression in Colorectal Cancer Inhibits the Phosphorylation of FAK Via VEGF

Background MicroRNAs (miRs) are small non-coding RNAs that play important roles in cancer development where they can act as oncogenes or as tumor-suppressors. MiR-34a is a tumor suppressor that is frequently downregulated in a number of tumor types. However, little is known about the role of miR-34a...

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Veröffentlicht in:	Digestive diseases and sciences 2014-05, Vol.59 (5), p.958-967
Hauptverfasser:	Zhang, Danhua, Zhou, Jianping, Dong, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis Binding Sites Biochemistry Cell Line, Tumor Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression Enzyme-linked immunosorbent assay Female Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Gastroenterology Gene Expression Regulation, Neoplastic - physiology Hepatology Humans Male Medicine Medicine & Public Health MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Oncology Original Article Phosphorylation Transplant Surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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