Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis
Background Ulcerative colitis (UC) is characterized with chronic, progressive inflammation of the gastrointestinal tract. The association of UC with cardiovascular disease is still a matter of debate. Aim The aim of this study was to investigate whether carotid intima-media thickness (CIMT) and caro...
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| Veröffentlicht in: | Digestive diseases and sciences 2013-08, Vol.58 (8), p.2293-2300 |
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| creator | Akdoğan, Remzi Adnan Durakoğlugil, Murtaza Emre Kocaman, Sinan Altan Çiçek, Yüksel Durakoğlugil, Tuğba Ergül, Elif Rakıcı, Halil |
| description | Background
Ulcerative colitis (UC) is characterized with chronic, progressive inflammation of the gastrointestinal tract. The association of UC with cardiovascular disease is still a matter of debate.
Aim
The aim of this study was to investigate whether carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of atherosclerosis and arterial stiffness are increased in patients with UC.
Methods
Our study was cross-sectional and observational in design. Baseline characteristics were recorded during interview with the patient. Patients with previous cardiovascular disease, rheumatoid arthritis, chronic renal failure, and infectious and inflammatory disorders other than UC were excluded. Thirty-seven consecutive patients with UC and 30 control participants underwent cf-PWV assessment and CIMT measurement. The diagnosis of UC was based on clinical, radiologic, endoscopic, and histological findings.
Results
CIMT, cf-PWV, and C reactive protein were significantly higher in patients with UC. Although linear regression analyses identified UC as an independent predictor of CIMT (
β
± SE, 0.39 ± 0.08;
p
|
| doi_str_mv | 10.1007/s10620-013-2634-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1942217394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712946377</galeid><sourcerecordid>A712946377</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-36abde199b8d0f5a933cae6d63bae9970b408902460af5e4bcf445876f15866e3</originalsourceid><addsrcrecordid>eNqFkk1vFSEUhonR2Gv1B7gxJG7cTOVrYFg2N2pvUmMXrS4JA2da6lyowGj678vNrZ_RGBbA4XnfnMM5CD2n5IgSol4XSiQjHaG8Y5KLTj9AK9qrduvl8BCtCJXtTKk8QE9KuSaEaEXlY3TAeE8GPYgV8pvoMtgCHp8tcwH8yX4F_BHm5EK9xTZ6vLY51eDxJtawtd178MHi86vgPkcoBYeIz2wNEGvB30K9whezg9wizWed5lBDeYoeTbaZP7vfD9HF2zfn65Pu9MO7zfr4tHNCsdpxaUcPVOtx8GTqrebcWZBe8tGC1oqMomVNmJDETj2I0U1C9IOSE-0HKYEfold735ucvixQqtmG4mCebYS0FEO1YIwqrsX_UUFVzwXjsqEv_0Cv05JjK2RHSdk-U_Gf1KWdwYQ4pZqt25maY0WZFpIr1aijv1BtedgGlyJMocV_E9C9wOVUSobJ3OTWhXxrKDG7ITD7ITBtCMxuCIxumhf3CS_jFvwPxfeuN4DtgdKe4iXkXyr6p-sdVXe5gQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1416623573</pqid></control><display><type>article</type><title>Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Akdoğan, Remzi Adnan ; Durakoğlugil, Murtaza Emre ; Kocaman, Sinan Altan ; Çiçek, Yüksel ; Durakoğlugil, Tuğba ; Ergül, Elif ; Rakıcı, Halil</creator><creatorcontrib>Akdoğan, Remzi Adnan ; Durakoğlugil, Murtaza Emre ; Kocaman, Sinan Altan ; Çiçek, Yüksel ; Durakoğlugil, Tuğba ; Ergül, Elif ; Rakıcı, Halil</creatorcontrib><description>Background
Ulcerative colitis (UC) is characterized with chronic, progressive inflammation of the gastrointestinal tract. The association of UC with cardiovascular disease is still a matter of debate.
Aim
The aim of this study was to investigate whether carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of atherosclerosis and arterial stiffness are increased in patients with UC.
Methods
Our study was cross-sectional and observational in design. Baseline characteristics were recorded during interview with the patient. Patients with previous cardiovascular disease, rheumatoid arthritis, chronic renal failure, and infectious and inflammatory disorders other than UC were excluded. Thirty-seven consecutive patients with UC and 30 control participants underwent cf-PWV assessment and CIMT measurement. The diagnosis of UC was based on clinical, radiologic, endoscopic, and histological findings.
Results
CIMT, cf-PWV, and C reactive protein were significantly higher in patients with UC. Although linear regression analyses identified UC as an independent predictor of CIMT (
β
± SE, 0.39 ± 0.08;
p
< 0.001), only age independently predicted cf-PWV (
β
± SE, 0.08 ± 0.03;
p
= 0.003) in our study population. Moreover, we revealed higher CIMT and PWV values in patients with higher disease activity and more extensive involvement, compared to patients with mild activity and limited disease.
Conclusion
We revealed increased pulse wave velocity and CIMT in patients with UC. UC appears to be associated with arterial stiffness and atherosclerotic burden, but the underlying mechanisms require further studies to be identified.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-013-2634-9</identifier><identifier>PMID: 23508984</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Analysis ; Arthritis ; Atherosclerosis ; Biochemistry ; C-reactive protein ; Cardiac patients ; Cardiovascular diseases ; Care and treatment ; Carotid Arteries - pathology ; Carotid Intima-Media Thickness ; Case-Control Studies ; Chronic kidney failure ; Colitis, Ulcerative - complications ; Cross-Sectional Studies ; Female ; Gastroenterology ; Hepatology ; Humans ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Multivariate Analysis ; Oncology ; Original Article ; Pulse Wave Analysis ; Rheumatoid factor ; Transplant Surgery ; Ulcerative colitis</subject><ispartof>Digestive diseases and sciences, 2013-08, Vol.58 (8), p.2293-2300</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer Science+Business Media, LLC 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-36abde199b8d0f5a933cae6d63bae9970b408902460af5e4bcf445876f15866e3</citedby><cites>FETCH-LOGICAL-c472t-36abde199b8d0f5a933cae6d63bae9970b408902460af5e4bcf445876f15866e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-013-2634-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-013-2634-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23508984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akdoğan, Remzi Adnan</creatorcontrib><creatorcontrib>Durakoğlugil, Murtaza Emre</creatorcontrib><creatorcontrib>Kocaman, Sinan Altan</creatorcontrib><creatorcontrib>Çiçek, Yüksel</creatorcontrib><creatorcontrib>Durakoğlugil, Tuğba</creatorcontrib><creatorcontrib>Ergül, Elif</creatorcontrib><creatorcontrib>Rakıcı, Halil</creatorcontrib><title>Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Ulcerative colitis (UC) is characterized with chronic, progressive inflammation of the gastrointestinal tract. The association of UC with cardiovascular disease is still a matter of debate.
Aim
The aim of this study was to investigate whether carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of atherosclerosis and arterial stiffness are increased in patients with UC.
Methods
Our study was cross-sectional and observational in design. Baseline characteristics were recorded during interview with the patient. Patients with previous cardiovascular disease, rheumatoid arthritis, chronic renal failure, and infectious and inflammatory disorders other than UC were excluded. Thirty-seven consecutive patients with UC and 30 control participants underwent cf-PWV assessment and CIMT measurement. The diagnosis of UC was based on clinical, radiologic, endoscopic, and histological findings.
Results
CIMT, cf-PWV, and C reactive protein were significantly higher in patients with UC. Although linear regression analyses identified UC as an independent predictor of CIMT (
β
± SE, 0.39 ± 0.08;
p
< 0.001), only age independently predicted cf-PWV (
β
± SE, 0.08 ± 0.03;
p
= 0.003) in our study population. Moreover, we revealed higher CIMT and PWV values in patients with higher disease activity and more extensive involvement, compared to patients with mild activity and limited disease.
Conclusion
We revealed increased pulse wave velocity and CIMT in patients with UC. UC appears to be associated with arterial stiffness and atherosclerotic burden, but the underlying mechanisms require further studies to be identified.</description><subject>Adult</subject><subject>Analysis</subject><subject>Arthritis</subject><subject>Atherosclerosis</subject><subject>Biochemistry</subject><subject>C-reactive protein</subject><subject>Cardiac patients</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Case-Control Studies</subject><subject>Chronic kidney failure</subject><subject>Colitis, Ulcerative - complications</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pulse Wave Analysis</subject><subject>Rheumatoid factor</subject><subject>Transplant Surgery</subject><subject>Ulcerative colitis</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkk1vFSEUhonR2Gv1B7gxJG7cTOVrYFg2N2pvUmMXrS4JA2da6lyowGj678vNrZ_RGBbA4XnfnMM5CD2n5IgSol4XSiQjHaG8Y5KLTj9AK9qrduvl8BCtCJXtTKk8QE9KuSaEaEXlY3TAeE8GPYgV8pvoMtgCHp8tcwH8yX4F_BHm5EK9xTZ6vLY51eDxJtawtd178MHi86vgPkcoBYeIz2wNEGvB30K9whezg9wizWed5lBDeYoeTbaZP7vfD9HF2zfn65Pu9MO7zfr4tHNCsdpxaUcPVOtx8GTqrebcWZBe8tGC1oqMomVNmJDETj2I0U1C9IOSE-0HKYEfold735ucvixQqtmG4mCebYS0FEO1YIwqrsX_UUFVzwXjsqEv_0Cv05JjK2RHSdk-U_Gf1KWdwYQ4pZqt25maY0WZFpIr1aijv1BtedgGlyJMocV_E9C9wOVUSobJ3OTWhXxrKDG7ITD7ITBtCMxuCIxumhf3CS_jFvwPxfeuN4DtgdKe4iXkXyr6p-sdVXe5gQ</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Akdoğan, Remzi Adnan</creator><creator>Durakoğlugil, Murtaza Emre</creator><creator>Kocaman, Sinan Altan</creator><creator>Çiçek, Yüksel</creator><creator>Durakoğlugil, Tuğba</creator><creator>Ergül, Elif</creator><creator>Rakıcı, Halil</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130801</creationdate><title>Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis</title><author>Akdoğan, Remzi Adnan ; Durakoğlugil, Murtaza Emre ; Kocaman, Sinan Altan ; Çiçek, Yüksel ; Durakoğlugil, Tuğba ; Ergül, Elif ; Rakıcı, Halil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-36abde199b8d0f5a933cae6d63bae9970b408902460af5e4bcf445876f15866e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Arthritis</topic><topic>Atherosclerosis</topic><topic>Biochemistry</topic><topic>C-reactive protein</topic><topic>Cardiac patients</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Case-Control Studies</topic><topic>Chronic kidney failure</topic><topic>Colitis, Ulcerative - complications</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pulse Wave Analysis</topic><topic>Rheumatoid factor</topic><topic>Transplant Surgery</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akdoğan, Remzi Adnan</creatorcontrib><creatorcontrib>Durakoğlugil, Murtaza Emre</creatorcontrib><creatorcontrib>Kocaman, Sinan Altan</creatorcontrib><creatorcontrib>Çiçek, Yüksel</creatorcontrib><creatorcontrib>Durakoğlugil, Tuğba</creatorcontrib><creatorcontrib>Ergül, Elif</creatorcontrib><creatorcontrib>Rakıcı, Halil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akdoğan, Remzi Adnan</au><au>Durakoğlugil, Murtaza Emre</au><au>Kocaman, Sinan Altan</au><au>Çiçek, Yüksel</au><au>Durakoğlugil, Tuğba</au><au>Ergül, Elif</au><au>Rakıcı, Halil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>58</volume><issue>8</issue><spage>2293</spage><epage>2300</epage><pages>2293-2300</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background
Ulcerative colitis (UC) is characterized with chronic, progressive inflammation of the gastrointestinal tract. The association of UC with cardiovascular disease is still a matter of debate.
Aim
The aim of this study was to investigate whether carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of atherosclerosis and arterial stiffness are increased in patients with UC.
Methods
Our study was cross-sectional and observational in design. Baseline characteristics were recorded during interview with the patient. Patients with previous cardiovascular disease, rheumatoid arthritis, chronic renal failure, and infectious and inflammatory disorders other than UC were excluded. Thirty-seven consecutive patients with UC and 30 control participants underwent cf-PWV assessment and CIMT measurement. The diagnosis of UC was based on clinical, radiologic, endoscopic, and histological findings.
Results
CIMT, cf-PWV, and C reactive protein were significantly higher in patients with UC. Although linear regression analyses identified UC as an independent predictor of CIMT (
β
± SE, 0.39 ± 0.08;
p
< 0.001), only age independently predicted cf-PWV (
β
± SE, 0.08 ± 0.03;
p
= 0.003) in our study population. Moreover, we revealed higher CIMT and PWV values in patients with higher disease activity and more extensive involvement, compared to patients with mild activity and limited disease.
Conclusion
We revealed increased pulse wave velocity and CIMT in patients with UC. UC appears to be associated with arterial stiffness and atherosclerotic burden, but the underlying mechanisms require further studies to be identified.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23508984</pmid><doi>10.1007/s10620-013-2634-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2013-08, Vol.58 (8), p.2293-2300 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1942217394 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Analysis Arthritis Atherosclerosis Biochemistry C-reactive protein Cardiac patients Cardiovascular diseases Care and treatment Carotid Arteries - pathology Carotid Intima-Media Thickness Case-Control Studies Chronic kidney failure Colitis, Ulcerative - complications Cross-Sectional Studies Female Gastroenterology Hepatology Humans Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Multivariate Analysis Oncology Original Article Pulse Wave Analysis Rheumatoid factor Transplant Surgery Ulcerative colitis |
| title | Increased Pulse Wave Velocity and Carotid Intima-Media Thickness in Patients with Ulcerative Colitis |
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