Upregulated HOXC8 Expression Is Associated with Poor Prognosis and Oxaliplatin Resistance in Hepatocellular Carcinoma

Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. It is indispensable to understanding molecular mechanisms of HCC progression and to developing clinically useful biomarkers for this disease. Aim In this article, we examined whether HOXC8 was as...

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Veröffentlicht in:	Digestive diseases and sciences 2015-11, Vol.60 (11), p.3351-3363
Hauptverfasser:	Xu, Pan, Zhang, Xiubing, Ni, Wenkai, Fan, Hui, Xu, Jian, Chen, Yongmei, Zhu, Jia, Gu, Xiaoling, Yang, Linlin, Ni, Runzhou, Chen, Buyou, Shi, Weidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Antineoplastic Agents - therapeutic use Biochemistry Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carrier Proteins - metabolism Caspase 3 - metabolism Cell Proliferation - drug effects Cyclin D1 - metabolism Drug Resistance, Neoplasm Female Gastroenterology Gene Expression Regulation, Neoplastic Health aspects Hep G2 Cells Hepatology Hepatoma Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunohistochemistry Kaplan-Meier Estimate Ki-67 Antigen - metabolism Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoplasm Grading Oncology Organoplatinum Compounds - therapeutic use Original Article Prognosis Proliferating Cell Nuclear Antigen - metabolism Proportional Hazards Models RNA Interference Signal Transduction - drug effects Time Factors Transfection Transplant Surgery Treatment Outcome Up-Regulation Young Adult
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