Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats
Introduction Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-i...
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| Veröffentlicht in: | Digestive diseases and sciences 2011-03, Vol.56 (3), p.715-720 |
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| creator | Tahan, Gulgun Gramignoli, Roberto Marongiu, Fabio Aktolga, Serdal Cetinkaya, Ali Tahan, Veysel Dorko, Kenneth |
| description | Introduction Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. Our study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats. Methods Wistar rats (n = 32) were divided into four groups. AA-induced colitis was performed in two of the groups, while the other two groups were injected with saline intrarectally. One of the AA-induced colitis groups and one of the control groups were administered 100 mg/kg/day melatonin intraperitoneally, and the pair groups were given saline. After 4 days, colonic changes were evaluated biochemically by measuring proinflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6], myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels in tissue homogenates and by histopathological examination. Results AA caused colonic mucosal injury, whereas melatonin suppressed these changes in the AA-induced colitis group (P < 0.001). AA administration resulted in increased TNF-α, IL-1β, IL-6, MPO, and MDA levels, and decreased GSH and SOD levels, whereas melatonin administration reversed these effects (all P < 0.001). Conclusions The present study proposes that melatonin has a dual action as an effective anti-inflammatory and an antioxidant, and may be a hopeful therapeutic agent for UC. |
| doi_str_mv | 10.1007/s10620-010-1364-5 |
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Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. Our study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats. Methods Wistar rats (n = 32) were divided into four groups. AA-induced colitis was performed in two of the groups, while the other two groups were injected with saline intrarectally. One of the AA-induced colitis groups and one of the control groups were administered 100 mg/kg/day melatonin intraperitoneally, and the pair groups were given saline. After 4 days, colonic changes were evaluated biochemically by measuring proinflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6], myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels in tissue homogenates and by histopathological examination. Results AA caused colonic mucosal injury, whereas melatonin suppressed these changes in the AA-induced colitis group (P < 0.001). AA administration resulted in increased TNF-α, IL-1β, IL-6, MPO, and MDA levels, and decreased GSH and SOD levels, whereas melatonin administration reversed these effects (all P < 0.001). Conclusions The present study proposes that melatonin has a dual action as an effective anti-inflammatory and an antioxidant, and may be a hopeful therapeutic agent for UC.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-010-1364-5</identifier><identifier>PMID: 20676767</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Acetic acid ; Acetic Acid - toxicity ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Anti-inflammatory drugs ; Antioxidants - therapeutic use ; Biochemistry ; Biological and medical sciences ; Colitis, Ulcerative - chemically induced ; Colitis, Ulcerative - drug therapy ; Colitis, Ulcerative - pathology ; Colon - drug effects ; Colon - metabolism ; Colon - pathology ; Cytokines - metabolism ; Disease Models, Animal ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Hydroxides ; Inflammation ; Interleukins ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Melatonin ; Melatonin - therapeutic use ; Oncology ; Organic acids ; Original Article ; Other diseases. Semiology ; Rats ; Rats, Wistar ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Superoxide ; Transplant Surgery ; Treatment Outcome ; Ulcerative colitis ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2011-03, Vol.56 (3), p.715-720</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-eea39a27977b7a8447556fff429f1da7593ce9a9b976e19f038c5b2fc91a89823</citedby><cites>FETCH-LOGICAL-c590t-eea39a27977b7a8447556fff429f1da7593ce9a9b976e19f038c5b2fc91a89823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-010-1364-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-010-1364-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23972487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20676767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tahan, Gulgun</creatorcontrib><creatorcontrib>Gramignoli, Roberto</creatorcontrib><creatorcontrib>Marongiu, Fabio</creatorcontrib><creatorcontrib>Aktolga, Serdal</creatorcontrib><creatorcontrib>Cetinkaya, Ali</creatorcontrib><creatorcontrib>Tahan, Veysel</creatorcontrib><creatorcontrib>Dorko, Kenneth</creatorcontrib><title>Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Introduction Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. Our study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats. Methods Wistar rats (n = 32) were divided into four groups. AA-induced colitis was performed in two of the groups, while the other two groups were injected with saline intrarectally. One of the AA-induced colitis groups and one of the control groups were administered 100 mg/kg/day melatonin intraperitoneally, and the pair groups were given saline. After 4 days, colonic changes were evaluated biochemically by measuring proinflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6], myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels in tissue homogenates and by histopathological examination. Results AA caused colonic mucosal injury, whereas melatonin suppressed these changes in the AA-induced colitis group (P < 0.001). AA administration resulted in increased TNF-α, IL-1β, IL-6, MPO, and MDA levels, and decreased GSH and SOD levels, whereas melatonin administration reversed these effects (all P < 0.001). Conclusions The present study proposes that melatonin has a dual action as an effective anti-inflammatory and an antioxidant, and may be a hopeful therapeutic agent for UC.</description><subject>Acetic acid</subject><subject>Acetic Acid - toxicity</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Anti-inflammatory drugs</subject><subject>Antioxidants - therapeutic use</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Colitis, Ulcerative - chemically induced</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colon - drug effects</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Hydroxides</subject><subject>Inflammation</subject><subject>Interleukins</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melatonin</subject><subject>Melatonin - therapeutic use</subject><subject>Oncology</subject><subject>Organic acids</subject><subject>Original Article</subject><subject>Other diseases. Semiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Superoxide</subject><subject>Transplant Surgery</subject><subject>Treatment Outcome</subject><subject>Ulcerative colitis</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks9u1DAQxiMEokvhAbhAVITEJcV24jg-RqsCKxWBCj1bXme8cuXYi-2U9jV4YpxmoQIhNAf_-32fx-MpiucYnWKE2NuIUUtQhTCqcN02FX1QrDBldUVo2z0sVgi3eY5xe1Q8ifEKIcQZbh8XRwS1bI5V8eMjWJm8M648u9kHiBFi-dl_h6AnW_Yumco4beU4ZircltINd7v-xgzSpbJXyVybZLLqAuJkk3G7Mput_bi3kKDcjPvgr2GEDHudeUhGVb0yQ7Vxw6RgyKzNDnGWXcgUnxaPtLQRnh3G4-Ly3dnX9Yfq_NP7zbo_rxTlKFUAsuaSMM7YlsmuaRilrda6IVzjQTLKawVc8i1nLWCuUd0puiVacSw73pH6uHiz-OYEv00QkxhNVGCtdOCnKDBvCMEU1SyjJ3-hV34KLmcnOkoYxt0d9GqBdtKCyFXzKUg1e4qeYcIp4ni-9fQfVI4BRqO8A23y_h8CvAhU8DEG0GIfzCjDrcBIzG0gljYQaF7nNhA0a14c8p22Iwy_Fb_-PQOvD4CMSlodpFMm3nM1Z6TpZo4sXMxHbgfh_uH_u_3lItLSC7kL2fjyC0G4Rrmk2ZnXPwHZq9MY</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Tahan, Gulgun</creator><creator>Gramignoli, Roberto</creator><creator>Marongiu, Fabio</creator><creator>Aktolga, Serdal</creator><creator>Cetinkaya, Ali</creator><creator>Tahan, Veysel</creator><creator>Dorko, Kenneth</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110301</creationdate><title>Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats</title><author>Tahan, Gulgun ; Gramignoli, Roberto ; Marongiu, Fabio ; Aktolga, Serdal ; Cetinkaya, Ali ; Tahan, Veysel ; Dorko, Kenneth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-eea39a27977b7a8447556fff429f1da7593ce9a9b976e19f038c5b2fc91a89823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetic acid</topic><topic>Acetic Acid - toxicity</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Anti-inflammatory drugs</topic><topic>Antioxidants - therapeutic use</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Colitis, Ulcerative - chemically induced</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Colon - drug effects</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatology</topic><topic>Hydroxides</topic><topic>Inflammation</topic><topic>Interleukins</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melatonin</topic><topic>Melatonin - therapeutic use</topic><topic>Oncology</topic><topic>Organic acids</topic><topic>Original Article</topic><topic>Other diseases. Semiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Superoxide</topic><topic>Transplant Surgery</topic><topic>Treatment Outcome</topic><topic>Ulcerative colitis</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tahan, Gulgun</creatorcontrib><creatorcontrib>Gramignoli, Roberto</creatorcontrib><creatorcontrib>Marongiu, Fabio</creatorcontrib><creatorcontrib>Aktolga, Serdal</creatorcontrib><creatorcontrib>Cetinkaya, Ali</creatorcontrib><creatorcontrib>Tahan, Veysel</creatorcontrib><creatorcontrib>Dorko, Kenneth</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tahan, Gulgun</au><au>Gramignoli, Roberto</au><au>Marongiu, Fabio</au><au>Aktolga, Serdal</au><au>Cetinkaya, Ali</au><au>Tahan, Veysel</au><au>Dorko, Kenneth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>56</volume><issue>3</issue><spage>715</spage><epage>720</epage><pages>715-720</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Introduction Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. Our study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats. Methods Wistar rats (n = 32) were divided into four groups. AA-induced colitis was performed in two of the groups, while the other two groups were injected with saline intrarectally. One of the AA-induced colitis groups and one of the control groups were administered 100 mg/kg/day melatonin intraperitoneally, and the pair groups were given saline. After 4 days, colonic changes were evaluated biochemically by measuring proinflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6], myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels in tissue homogenates and by histopathological examination. Results AA caused colonic mucosal injury, whereas melatonin suppressed these changes in the AA-induced colitis group (P < 0.001). AA administration resulted in increased TNF-α, IL-1β, IL-6, MPO, and MDA levels, and decreased GSH and SOD levels, whereas melatonin administration reversed these effects (all P < 0.001). Conclusions The present study proposes that melatonin has a dual action as an effective anti-inflammatory and an antioxidant, and may be a hopeful therapeutic agent for UC.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>20676767</pmid><doi>10.1007/s10620-010-1364-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Acetic acid Acetic Acid - toxicity Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Anti-inflammatory drugs Antioxidants - therapeutic use Biochemistry Biological and medical sciences Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology Colon - drug effects Colon - metabolism Colon - pathology Cytokines - metabolism Disease Models, Animal Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Hydroxides Inflammation Interleukins Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Medical sciences Medicine Medicine & Public Health Melatonin Melatonin - therapeutic use Oncology Organic acids Original Article Other diseases. Semiology Rats Rats, Wistar Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Superoxide Transplant Surgery Treatment Outcome Ulcerative colitis Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats |
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