Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft

Temozolomide is a DNA-methylating agent used in the treatment of malignant gliomas. In this study, we have examined if inhibition of poly(ADP-ribose) polymerase (PARP) could increase the cytotoxicity of temozolomide, particularly in cells deficient in DNA mismatch repair. Athymic mice, transplanted...

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Veröffentlicht in:	Molecular cancer therapeutics 2005-09, Vol.4 (9), p.1364-1368
Hauptverfasser:	Cheng, C Lynn, Johnson, Stewart P, Keir, Stephen T, Quinn, Jennifer A, Ali-Osman, Francis, Szabo, Csaba, Li, Hongshan, Salzman, Andrew L, Dolan, M Eileen, Modrich, Paul, Bigner, Darell D, Friedman, Henry S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - pharmacology Base Pair Mismatch Dacarbazine - analogs & derivatives Dacarbazine - pharmacology DNA mismatch repair DNA Repair Drug Resistance, Neoplasm - drug effects glioma Indoles - pharmacology Medulloblastoma - drug therapy Medulloblastoma - enzymology Medulloblastoma - genetics Mice Mice, Inbred BALB C Mice, Nude PARP Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Temozolomide Transplantation, Heterologous Tumor Cells, Cultured
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