Effects of ultra-/diafiltration conditions on present aggregates in human immunoglobulin G preparations

Small traces of aggregates may cause reduced stability of human immunoglobulin G preparations. Ultra-/diafiltration as last step before formulation could also contribute to aggregate formation or depletion. One of the key challenges is to find a sensitive analytical method for the early detection of...

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Veröffentlicht in:	Journal of membrane science 2006-04, Vol.274 (1), p.108-115
Hauptverfasser:	Ahrer, K., Buchacher, A., Iberer, G., Jungbauer, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Cross-flow filtration Immunoglobulin Ionic strength Light scattering
Online-Zugang:	Volltext
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