Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)

Autoimmunity is prevented by the function of the autoimmune regulator [AIRE (Aire in mice)], which promotes the expression of a wide variety of tissue-restricted antigens (TRAs) from medullary thymic epithelial cells (mTECs) and from a subset of peripheral antigen-presenting cells (APCs). We examine...

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Veröffentlicht in:	Journal of autoimmunity 2018-01, Vol.86, p.75-92
Hauptverfasser:	Nishijima, Hitoshi, Kajimoto, Tatsuya, Matsuoka, Yoshiki, Mouri, Yasuhiro, Morimoto, Junko, Matsumoto, Minoru, Kawano, Hiroshi, Nishioka, Yasuhiko, Uehara, Hisanori, Izumi, Keisuke, Tsuneyama, Koichi, Okazaki, Il-mi, Okazaki, Taku, Hosomichi, Kazuyoshi, Shiraki, Ayako, Shibutani, Makoto, Mitsumori, Kunitoshi, Matsumoto, Mitsuru
Format:	Artikel
Sprache:	eng
Schlagworte:	AIRE AIRE Protein Animals Autoantigens - metabolism Autoimmunity Diabetes Mellitus, Type 1 - immunology Disease Models, Animal Humans Immune Tolerance Medullary thymic epithelial cell (mTEC) Mice Mice, Inbred NOD Mice, Transgenic Muscle Muscles - immunology Organ Specificity Polymyositis - immunology Thymus Gland - immunology Tolerance Transcription Factors - genetics Transcription Factors - metabolism
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