Targeting epithelial-mesenchymal plasticity in cancer: clinical and preclinical advances in therapy and monitoring

The concept of epithelial-mesenchymal plasticity (EMP), which describes the dynamic flux within the spectrum of phenotypic states that invasive carcinoma cells may reside, is being increasingly recognised for its role in cancer progression and therapy resistance. The myriad of events that are able t...

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Veröffentlicht in:	Biochemical journal 2017-10, Vol.474 (19), p.3269-3306
Hauptverfasser:	Bhatia, Sugandha, Monkman, James, Toh, Alan Kie Leong, Nagaraj, Shivashankar H, Thompson, Erik W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Monitoring Drug Repositioning Epigenesis, Genetic Epithelial-Mesenchymal Transition - genetics Humans MicroRNAs - genetics MicroRNAs - metabolism Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy
Online-Zugang:	Volltext
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