Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy

Cough is the most common reason to visit a primary care physician, yet it remains an unmet medical need. Fatty acid amide hydrolase (FAAH) is an enzyme that breaks down endocannabinoids, and inhibition of FAAH produces analgesic and anti-inflammatory effects. Cannabinoids inhibit vagal sensory nerve...

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Veröffentlicht in:	The European respiratory journal 2017-09, Vol.50 (3), p.1700782-1700782
Hauptverfasser:	Wortley, Michael A, Adcock, John J, Dubuis, Eric D, Maher, Sarah A, Bonvini, Sara J, Delescluse, Isabelle, Kinloch, Ross, McMurray, Gordon, Perros-Huguet, Christelle, Papakosta, Marianthi, Birrell, Mark A, Belvisi, Maria G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amides Amidohydrolases - antagonists & inhibitors Analgesics Anandamide Animals Antitussive Agents - therapeutic use Aza Compounds - pharmacology Calcium channels Cannabinoid CB2 receptors Cannabinoid Receptor Modulators - pharmacology Cannabinoids - antagonists & inhibitors Capsaicin - pharmacology Cough Cough - drug therapy Electrophysiology Enzyme Inhibitors - therapeutic use Fatty acids Fatty-acid amide hydrolase Female Guinea Pigs Humans Hydrolase Inflammation Male Middle Aged Oleic acid Palmitoylethanolamide Phosphoprotein phosphatase Potassium channels Primary care Protein phosphatase Receptor, Cannabinoid, CB2 - drug effects Respiratory tract Spiro Compounds - pharmacology Vagus nerve Vagus Nerve - drug effects
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