Polyglutamine expansion diseases: More than simple repeats

Polyglutamine (polyQ) repeat-containing proteins are widespread in the human proteome but only nine of them are associated with highly incapacitating neurodegenerative disorders. The genetic expansion of the polyQ tract in disease-related proteins triggers a series of events resulting in neurodegene...

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Veröffentlicht in:	Journal of structural biology 2018-02, Vol.201 (2), p.139-154
Hauptverfasser:	Silva, Alexandra, de Almeida, Ana Viana, Macedo-Ribeiro, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation modulation Ataxin-3 Molecular partner Neurodegenerative disease Polyglutamine protein Post-translational modification
Online-Zugang:	Volltext
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