Evaluation of proinflammatory and immunosuppressive cytokines in blood and bone marrow of healthy hematopoietic stem cell donors

•The first study comparing cytokine concentration, expression of CD47 and CD274 immunosuppressive proteins on HSCs in bone marrow and blood of hematopoietic stem cells donors.•Concentration of proinflammatory cytokines is higher in blood than in bone marrow.•TGFβ is present at very high concentratio...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2018-02, Vol.102, p.181-186
Hauptverfasser:	Fidyk, Wojciech, Mitrus, Iwona, Ciomber, Agnieszka, Smagur, Andrzej, Chwieduk, Agata, Głowala-Kosińska, Magdalena, Giebel, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bone marrow Bone Marrow - immunology Bone Marrow - metabolism CD274 CD47 Cytokine levels Cytokines - blood Cytokines - metabolism Female Healthy Volunteers Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Humans Immune privilege Immunosuppressive Agents - blood Immunosuppressive Agents - metabolism Inflammation Mediators - blood Male Middle Aged Peripheral Blood Stem Cell Transplantation Stem Cell Niche - immunology Stem Cell Niche - physiology Stem cells Tissue Donors Young Adult
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