BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer

Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis. Bone morphogenetic protein (BMP)-dependent signaling arising from stro...

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Veröffentlicht in:	Clinical cancer research 2017-12, Vol.23 (23), p.7388-7399
Hauptverfasser:	Martínez, Víctor G, Rubio, Carolina, Martínez-Fernández, Mónica, Segovia, Cristina, López-Calderón, Fernando, Garín, Marina I, Teijeira, Alicia, Munera-Maravilla, Ester, Varas, Alberto, Sacedón, Rosa, Guerrero, Félix, Villacampa, Felipe, de la Rosa, Federico, Castellano, Daniel, López-Collazo, Eduardo, Paramio, Jesús M, Vicente, Ángeles, Dueñas, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Bladder Bladder cancer Bone morphogenetic protein 4 Bone morphogenetic protein receptor type II Cancer Cell differentiation Conditioning Differentiation (biology) Experimental design Homeostasis Interleukin 1 Interleukin 10 Invasiveness Ligands Macrophages Mesenchyme Metastases Monocytes Muscles Patients Peripheral blood Polarization Signaling Smad protein Tumor cell lines Tumor cells Tumors Urinary bladder Urothelial cancer
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