Bioisosteric hybrids of two anti-inflammatory agents, rutaecarpine and piroxicam

Bioisosteric replacements were accomplished by building the structural elements of piroxicam, an anti-inflammatory drug, into the pentacyclic system of rutaecarpine, a quinazolinocarboline alkaloid, in order to modify activity and selectivity on COX-isoenzymes. The pentacyclic compounds were synthes...

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Veröffentlicht in:	Tetrahedron letters 2008-09, Vol.49 (40), p.5711-5713
Hauptverfasser:	Bubenyák, Máté, Noszál, Béla, Kóczián, Kristóf, Takács, Mária, Béni, Szabolcs, Hermecz, István, Kökösi, József
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloid analogues Anti-inflammatory drug Bioisosteric hybrid Piroxicam Rutaecarpine
Online-Zugang:	Volltext
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