Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels
Objective: We assessed whether umbilical cord blood placental growth factor (PlGF) levels at delivery are associated with fetal growth. Methods: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern,...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2018-01, Vol.43 (1), p.26-33 |
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| creator | Broere-Brown, Zoe A. Schalekamp-Timmermans, Sarah Jaddoe, Vincent W.V. Steegers, Eric A.P. |
| description | Objective: We assessed whether umbilical cord blood placental growth factor (PlGF) levels at delivery are associated with fetal growth. Methods: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern, and fetal growth restriction (FGR; decrease in growth between the second trimester and birth of ≥40 percentiles). In all analyses the highest PlGF multiple of the median (MoM) quintile was used as the reference category. Results: Umbilical cord PlGF was neither correlated with maternal second-trimester PlGF (p = 0.08) nor placental weight (p = 0.18), suggesting that PlGF from umbilical cord blood was of fetal origin. Lower PlGF MoM quintiles were associated with a lower birth weight (lowest quintile -0.60 standard deviation [95% confidence interval -0.71 to -0.48, p for trend |
| doi_str_mv | 10.1159/000475547 |
| format | Article |
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Methods: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern, and fetal growth restriction (FGR; decrease in growth between the second trimester and birth of ≥40 percentiles). In all analyses the highest PlGF multiple of the median (MoM) quintile was used as the reference category. Results: Umbilical cord PlGF was neither correlated with maternal second-trimester PlGF (p = 0.08) nor placental weight (p = 0.18), suggesting that PlGF from umbilical cord blood was of fetal origin. Lower PlGF MoM quintiles were associated with a lower birth weight (lowest quintile -0.60 standard deviation [95% confidence interval -0.71 to -0.48, p for trend <0.001]) and a different fetal growth pattern (p < 0.001). Finally, lower PlGF MoM quintiles were associated with FGR (lowest quintile odds ratio 2.00 [95% confidence interval 1.25 to 3.21, p for trend <0.001]). Conclusion: Lower umbilical cord PlGF levels are associated with lower birth weight, deviating fetal growth patterns, and a higher odds of FGR. Hence, cord blood PlGF might be a promising biomarker to determine deviations in fetal growth and FGR retrospectively, enabling follow-up of these neonates.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000475547</identifier><identifier>PMID: 28926825</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Analysis ; Biomarkers - blood ; Birth Weight ; Chi-Square Distribution ; Female ; Fetal Blood - metabolism ; Fetal Development ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - diagnostic imaging ; Fetal Growth Retardation - physiopathology ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Linear Models ; Logistic Models ; Newborn infants ; Odds Ratio ; Original Paper ; Parturition ; Placenta Growth Factor - blood ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - physiopathology ; Pregnancy ; Pregnancy Trimesters - blood ; Prospective Studies ; Risk Factors ; Ultrasonography, Prenatal ; Young Adult</subject><ispartof>Fetal diagnosis and therapy, 2018-01, Vol.43 (1), p.26-33</ispartof><rights>The Author(s). Published by S. Karger AG, Basel</rights><rights>2017 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2018 S. Karger AG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-190b3a62f581c421914a847064d290efd794a584eab643def8d4e98667fd814e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2423,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28926825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broere-Brown, Zoe A.</creatorcontrib><creatorcontrib>Schalekamp-Timmermans, Sarah</creatorcontrib><creatorcontrib>Jaddoe, Vincent W.V.</creatorcontrib><creatorcontrib>Steegers, Eric A.P.</creatorcontrib><title>Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>Objective: We assessed whether umbilical cord blood placental growth factor (PlGF) levels at delivery are associated with fetal growth. Methods: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern, and fetal growth restriction (FGR; decrease in growth between the second trimester and birth of ≥40 percentiles). In all analyses the highest PlGF multiple of the median (MoM) quintile was used as the reference category. Results: Umbilical cord PlGF was neither correlated with maternal second-trimester PlGF (p = 0.08) nor placental weight (p = 0.18), suggesting that PlGF from umbilical cord blood was of fetal origin. Lower PlGF MoM quintiles were associated with a lower birth weight (lowest quintile -0.60 standard deviation [95% confidence interval -0.71 to -0.48, p for trend <0.001]) and a different fetal growth pattern (p < 0.001). Finally, lower PlGF MoM quintiles were associated with FGR (lowest quintile odds ratio 2.00 [95% confidence interval 1.25 to 3.21, p for trend <0.001]). Conclusion: Lower umbilical cord PlGF levels are associated with lower birth weight, deviating fetal growth patterns, and a higher odds of FGR. Hence, cord blood PlGF might be a promising biomarker to determine deviations in fetal growth and FGR retrospectively, enabling follow-up of these neonates.</description><subject>Adult</subject><subject>Analysis</subject><subject>Biomarkers - blood</subject><subject>Birth Weight</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Fetal Development</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - diagnostic imaging</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Linear Models</subject><subject>Logistic Models</subject><subject>Newborn infants</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Parturition</subject><subject>Placenta Growth Factor - blood</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimesters - blood</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Ultrasonography, Prenatal</subject><subject>Young Adult</subject><issn>1015-3837</issn><issn>1421-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><recordid>eNpt0c9LwzAUB_Agij-mB-8iBUH0UE3apE2OczoVBnrQc0mTV1dNm5m0iv-9kc7hQHJI-PJ5SR4PoUOCLwhh4hJjTHPGaL6BdglNSCxERjfDGRMWpzzNd9Ce96-B8TzNttFOwkWS8YTtouspdNJEt85-dvNItjp6NFJB-yecStVZFz03ZW1qFfKJdTq6MtbqaAYfYPw-2qqk8XCw3EfoeXrzNLmLZw-395PxLFY0FV1MBC5TmSUV40SFbwpCJac5zqhOBIZK54JKxinIMqOphoprCoJnWV5pTiikI3Q23Ltw9r0H3xVN7RUYI1uwvS-IoASLHIeWR-hkoC_SQFG3le2cVD-8GIfncZJyxoK6-EeFpaGplW2hqkO-VnD6p2AO0nRzb03f1bb16_B8gMpZ7x1UxcLVjXRfBcHFz9CK1dCCPV621ZcN6JX8nVIARwN4k-4F3Aos678BikGVvg</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Broere-Brown, Zoe A.</creator><creator>Schalekamp-Timmermans, Sarah</creator><creator>Jaddoe, Vincent W.V.</creator><creator>Steegers, Eric A.P.</creator><general>S. Karger AG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels</title><author>Broere-Brown, Zoe A. ; Schalekamp-Timmermans, Sarah ; Jaddoe, Vincent W.V. ; Steegers, Eric A.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-190b3a62f581c421914a847064d290efd794a584eab643def8d4e98667fd814e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Biomarkers - blood</topic><topic>Birth Weight</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Fetal Development</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - diagnostic imaging</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Humans</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Linear Models</topic><topic>Logistic Models</topic><topic>Newborn infants</topic><topic>Odds Ratio</topic><topic>Original Paper</topic><topic>Parturition</topic><topic>Placenta Growth Factor - blood</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimesters - blood</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Ultrasonography, Prenatal</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broere-Brown, Zoe A.</creatorcontrib><creatorcontrib>Schalekamp-Timmermans, Sarah</creatorcontrib><creatorcontrib>Jaddoe, Vincent W.V.</creatorcontrib><creatorcontrib>Steegers, Eric A.P.</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broere-Brown, Zoe A.</au><au>Schalekamp-Timmermans, Sarah</au><au>Jaddoe, Vincent W.V.</au><au>Steegers, Eric A.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2018-01</date><risdate>2018</risdate><volume>43</volume><issue>1</issue><spage>26</spage><epage>33</epage><pages>26-33</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>Objective: We assessed whether umbilical cord blood placental growth factor (PlGF) levels at delivery are associated with fetal growth. Methods: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern, and fetal growth restriction (FGR; decrease in growth between the second trimester and birth of ≥40 percentiles). In all analyses the highest PlGF multiple of the median (MoM) quintile was used as the reference category. Results: Umbilical cord PlGF was neither correlated with maternal second-trimester PlGF (p = 0.08) nor placental weight (p = 0.18), suggesting that PlGF from umbilical cord blood was of fetal origin. Lower PlGF MoM quintiles were associated with a lower birth weight (lowest quintile -0.60 standard deviation [95% confidence interval -0.71 to -0.48, p for trend <0.001]) and a different fetal growth pattern (p < 0.001). Finally, lower PlGF MoM quintiles were associated with FGR (lowest quintile odds ratio 2.00 [95% confidence interval 1.25 to 3.21, p for trend <0.001]). Conclusion: Lower umbilical cord PlGF levels are associated with lower birth weight, deviating fetal growth patterns, and a higher odds of FGR. Hence, cord blood PlGF might be a promising biomarker to determine deviations in fetal growth and FGR retrospectively, enabling follow-up of these neonates.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>28926825</pmid><doi>10.1159/000475547</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Biomarkers - blood Birth Weight Chi-Square Distribution Female Fetal Blood - metabolism Fetal Development Fetal Growth Retardation - blood Fetal Growth Retardation - diagnostic imaging Fetal Growth Retardation - physiopathology Humans Infant, Low Birth Weight Infant, Newborn Linear Models Logistic Models Newborn infants Odds Ratio Original Paper Parturition Placenta Growth Factor - blood Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - physiopathology Pregnancy Pregnancy Trimesters - blood Prospective Studies Risk Factors Ultrasonography, Prenatal Young Adult |
| title | Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels |
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