The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women
Collagen type I plays an important role in the bone matrix and is encoded by COL1A2 (collagen type I alpha 2) gene that may be a potential candidate for osteoporotic fracture. The aim of this study is to determine whether EcoRI, Del38 and PvuII polymorphisms of COL1A2 are associated with the develop...
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| Veröffentlicht in: | Ginekologia polska 2017-01, Vol.88 (8), p.414-420 |
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| creator | Majchrzycki, Marian Bartkowiak-Wieczorek, Joanna Bogacz, Anna Szyfter-Harris, Joanna Wolski, Hubert Klejewski, Andrzej Goch, Maciej Drews, Krzysztof Barlik, Magdalena Ożarowski, Marcin Kamiński, Adam Gryszczyńska, Agnieszka Seremak-Mrozikiewicz, Agnieszka |
| description | Collagen type I plays an important role in the bone matrix and is encoded by COL1A2 (collagen type I alpha 2) gene that may be a potential candidate for osteoporotic fracture. The aim of this study is to determine whether EcoRI, Del38 and PvuII polymorphisms of COL1A2 are associated with the development of osteoporosis and osteopenia in post-menopausal Polish women. Moreover, analysis of relationship between frequency of COL1A2 gene polymorphic variants and clinical parameters of bone turnover and degree of osteoporosis was performed.
The study group comprised of women with osteoporosis (n = 90), osteopenia (n = 56) and healthy individuals (n = 56). The EcoRI, Del38 and PvuII polymorphisms in COL1A2 gene were detected by PCR-RFLP method.
In women with osteoporosis the TT genotype of EcoRI polymorphism had the lowest Z-score value compared to other genotypes (p = 0.034). In case of Del28 polymorphism, there was a statistically significant correlation between lower BMI values and the DD genotype in women with osteopenia (p = 0.041). There was no statistically significant correlation between polymorphic variants of Del28 polymorphism and clinical parameters of women with osteoporosis. The analysis of PvuII polymorphism showed that in women with osteopenia the CC genotype had the lowest body weight compared to other genotypes (p = 0.039). PvuII polymorphism and clinical parameters in the group of women with osteoporosis had no statistically significant correlations.
The analyzed COL1A2 polymorphisms seem to be related to osteoporosis development and their particular clinical parameters. Hence, the COL1A2 polymorphism may be a genetic risk factor related to the development of osteoporosis. |
| doi_str_mv | 10.5603/GP.A2017.0077 |
| format | Article |
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The study group comprised of women with osteoporosis (n = 90), osteopenia (n = 56) and healthy individuals (n = 56). The EcoRI, Del38 and PvuII polymorphisms in COL1A2 gene were detected by PCR-RFLP method.
In women with osteoporosis the TT genotype of EcoRI polymorphism had the lowest Z-score value compared to other genotypes (p = 0.034). In case of Del28 polymorphism, there was a statistically significant correlation between lower BMI values and the DD genotype in women with osteopenia (p = 0.041). There was no statistically significant correlation between polymorphic variants of Del28 polymorphism and clinical parameters of women with osteoporosis. The analysis of PvuII polymorphism showed that in women with osteopenia the CC genotype had the lowest body weight compared to other genotypes (p = 0.039). PvuII polymorphism and clinical parameters in the group of women with osteoporosis had no statistically significant correlations.
The analyzed COL1A2 polymorphisms seem to be related to osteoporosis development and their particular clinical parameters. Hence, the COL1A2 polymorphism may be a genetic risk factor related to the development of osteoporosis.</description><identifier>ISSN: 0017-0011</identifier><identifier>EISSN: 2543-6767</identifier><identifier>DOI: 10.5603/GP.A2017.0077</identifier><identifier>PMID: 28930368</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Bone Diseases, Metabolic - genetics ; Collagen ; Collagen Type I - genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Humans ; Middle Aged ; Osteoporosis ; Osteoporosis, Postmenopausal - genetics ; Poland ; Polymorphism ; Polymorphism, Genetic</subject><ispartof>Ginekologia polska, 2017-01, Vol.88 (8), p.414-420</ispartof><rights>2017. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-cbb7ca0ef0b6bde736e489a87f9522018fcd2f249765faf944e2637aa39fb15e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28930368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Majchrzycki, Marian</creatorcontrib><creatorcontrib>Bartkowiak-Wieczorek, Joanna</creatorcontrib><creatorcontrib>Bogacz, Anna</creatorcontrib><creatorcontrib>Szyfter-Harris, Joanna</creatorcontrib><creatorcontrib>Wolski, Hubert</creatorcontrib><creatorcontrib>Klejewski, Andrzej</creatorcontrib><creatorcontrib>Goch, Maciej</creatorcontrib><creatorcontrib>Drews, Krzysztof</creatorcontrib><creatorcontrib>Barlik, Magdalena</creatorcontrib><creatorcontrib>Ożarowski, Marcin</creatorcontrib><creatorcontrib>Kamiński, Adam</creatorcontrib><creatorcontrib>Gryszczyńska, Agnieszka</creatorcontrib><creatorcontrib>Seremak-Mrozikiewicz, Agnieszka</creatorcontrib><title>The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women</title><title>Ginekologia polska</title><addtitle>Ginekol Pol</addtitle><description>Collagen type I plays an important role in the bone matrix and is encoded by COL1A2 (collagen type I alpha 2) gene that may be a potential candidate for osteoporotic fracture. The aim of this study is to determine whether EcoRI, Del38 and PvuII polymorphisms of COL1A2 are associated with the development of osteoporosis and osteopenia in post-menopausal Polish women. Moreover, analysis of relationship between frequency of COL1A2 gene polymorphic variants and clinical parameters of bone turnover and degree of osteoporosis was performed.
The study group comprised of women with osteoporosis (n = 90), osteopenia (n = 56) and healthy individuals (n = 56). The EcoRI, Del38 and PvuII polymorphisms in COL1A2 gene were detected by PCR-RFLP method.
In women with osteoporosis the TT genotype of EcoRI polymorphism had the lowest Z-score value compared to other genotypes (p = 0.034). In case of Del28 polymorphism, there was a statistically significant correlation between lower BMI values and the DD genotype in women with osteopenia (p = 0.041). There was no statistically significant correlation between polymorphic variants of Del28 polymorphism and clinical parameters of women with osteoporosis. The analysis of PvuII polymorphism showed that in women with osteopenia the CC genotype had the lowest body weight compared to other genotypes (p = 0.039). PvuII polymorphism and clinical parameters in the group of women with osteoporosis had no statistically significant correlations.
The analyzed COL1A2 polymorphisms seem to be related to osteoporosis development and their particular clinical parameters. Hence, the COL1A2 polymorphism may be a genetic risk factor related to the development of osteoporosis.</description><subject>Bone Diseases, Metabolic - genetics</subject><subject>Collagen</subject><subject>Collagen Type I - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - genetics</subject><subject>Poland</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><issn>0017-0011</issn><issn>2543-6767</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9r3DAQxUVpSZYkx1yLoJf04I3-WbKOy9JuCwvJIT0LWR41DrakWnZCvkQ_c2Wy7aE6aHiP3wwaPYSuKdnWkvDbw_12xwhVW0KUeoc2rBa8kkqq92hDil-Vi56jq5yfSDmSKab1GTpnjeaEy2aDfj88Au7HFKfZBgc4epzi8DrGKT32Dj_bqbdhzqvv4jDYnxAw3TFcKuCb_d2xiM-4D3guczp4hiGmEcK8NsQ8Q0wQeott6E4yTjH3ee1IxShoTHbJdsAvsYhL9MHbIcPVqV6gH1-_POy_Vce7w_f97lg5LslcubZVzhLwpJVtB4pLEI22jfK6ZuVDGu865pnQStbeei0EMMmVtVz7ltbAL9DN29w0xV8L5NmMfXZQFgwQl2yoFpTommpd0E__oU9xmUJ5nWFCCkYZaUShqjfKlf3yBN6kqR_t9GooMWtW5nBv7JqVWbMq_MfT1KUdoftH_02G_wEaK4_A</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Majchrzycki, Marian</creator><creator>Bartkowiak-Wieczorek, Joanna</creator><creator>Bogacz, Anna</creator><creator>Szyfter-Harris, Joanna</creator><creator>Wolski, Hubert</creator><creator>Klejewski, Andrzej</creator><creator>Goch, Maciej</creator><creator>Drews, Krzysztof</creator><creator>Barlik, Magdalena</creator><creator>Ożarowski, Marcin</creator><creator>Kamiński, Adam</creator><creator>Gryszczyńska, Agnieszka</creator><creator>Seremak-Mrozikiewicz, Agnieszka</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women</title><author>Majchrzycki, Marian ; Bartkowiak-Wieczorek, Joanna ; Bogacz, Anna ; Szyfter-Harris, Joanna ; Wolski, Hubert ; Klejewski, Andrzej ; Goch, Maciej ; Drews, Krzysztof ; Barlik, Magdalena ; Ożarowski, Marcin ; Kamiński, Adam ; Gryszczyńska, Agnieszka ; Seremak-Mrozikiewicz, Agnieszka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-cbb7ca0ef0b6bde736e489a87f9522018fcd2f249765faf944e2637aa39fb15e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bone Diseases, Metabolic - genetics</topic><topic>Collagen</topic><topic>Collagen Type I - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - genetics</topic><topic>Poland</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Majchrzycki, Marian</creatorcontrib><creatorcontrib>Bartkowiak-Wieczorek, Joanna</creatorcontrib><creatorcontrib>Bogacz, Anna</creatorcontrib><creatorcontrib>Szyfter-Harris, Joanna</creatorcontrib><creatorcontrib>Wolski, Hubert</creatorcontrib><creatorcontrib>Klejewski, Andrzej</creatorcontrib><creatorcontrib>Goch, Maciej</creatorcontrib><creatorcontrib>Drews, Krzysztof</creatorcontrib><creatorcontrib>Barlik, Magdalena</creatorcontrib><creatorcontrib>Ożarowski, Marcin</creatorcontrib><creatorcontrib>Kamiński, Adam</creatorcontrib><creatorcontrib>Gryszczyńska, Agnieszka</creatorcontrib><creatorcontrib>Seremak-Mrozikiewicz, Agnieszka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Ginekologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Majchrzycki, Marian</au><au>Bartkowiak-Wieczorek, Joanna</au><au>Bogacz, Anna</au><au>Szyfter-Harris, Joanna</au><au>Wolski, Hubert</au><au>Klejewski, Andrzej</au><au>Goch, Maciej</au><au>Drews, Krzysztof</au><au>Barlik, Magdalena</au><au>Ożarowski, Marcin</au><au>Kamiński, Adam</au><au>Gryszczyńska, Agnieszka</au><au>Seremak-Mrozikiewicz, Agnieszka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women</atitle><jtitle>Ginekologia polska</jtitle><addtitle>Ginekol Pol</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>88</volume><issue>8</issue><spage>414</spage><epage>420</epage><pages>414-420</pages><issn>0017-0011</issn><eissn>2543-6767</eissn><abstract>Collagen type I plays an important role in the bone matrix and is encoded by COL1A2 (collagen type I alpha 2) gene that may be a potential candidate for osteoporotic fracture. The aim of this study is to determine whether EcoRI, Del38 and PvuII polymorphisms of COL1A2 are associated with the development of osteoporosis and osteopenia in post-menopausal Polish women. Moreover, analysis of relationship between frequency of COL1A2 gene polymorphic variants and clinical parameters of bone turnover and degree of osteoporosis was performed.
The study group comprised of women with osteoporosis (n = 90), osteopenia (n = 56) and healthy individuals (n = 56). The EcoRI, Del38 and PvuII polymorphisms in COL1A2 gene were detected by PCR-RFLP method.
In women with osteoporosis the TT genotype of EcoRI polymorphism had the lowest Z-score value compared to other genotypes (p = 0.034). In case of Del28 polymorphism, there was a statistically significant correlation between lower BMI values and the DD genotype in women with osteopenia (p = 0.041). There was no statistically significant correlation between polymorphic variants of Del28 polymorphism and clinical parameters of women with osteoporosis. The analysis of PvuII polymorphism showed that in women with osteopenia the CC genotype had the lowest body weight compared to other genotypes (p = 0.039). PvuII polymorphism and clinical parameters in the group of women with osteoporosis had no statistically significant correlations.
The analyzed COL1A2 polymorphisms seem to be related to osteoporosis development and their particular clinical parameters. Hence, the COL1A2 polymorphism may be a genetic risk factor related to the development of osteoporosis.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>28930368</pmid><doi>10.5603/GP.A2017.0077</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bone Diseases, Metabolic - genetics Collagen Collagen Type I - genetics Female Genetic Predisposition to Disease Genotype Genotype & phenotype Humans Middle Aged Osteoporosis Osteoporosis, Postmenopausal - genetics Poland Polymorphism Polymorphism, Genetic |
| title | The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women |
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