Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat
The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid...
Gespeichert in:
| Veröffentlicht in: | Human & experimental toxicology 2008-07, Vol.27 (7), p.547-552 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 552 |
|---|---|
| container_issue | 7 |
| container_start_page | 547 |
| container_title | Human & experimental toxicology |
| container_volume | 27 |
| creator | Armagan, A Uzar, E Uz, E Yilmaz, HR Kutluhan, S Koyuncuoglu, HR Soyupek, S Cam, H Serel, TA |
| description | The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-treated. In the second day of experiment, a single dose of methotrexate was intraperitoneally administered to groups II and III, although a daily single dose of caffeic acid phenethyl ester was intraperitoneally administered to group III for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. In the tissue, the level of lipid peroxidation as malondialdehyde and activities of superoxide dismutase were higher in the methotrexate group than in the control group. Lipid peroxidation levels and superoxide dismutase activities were decreased in caffeic acid phenethyl ester + methotrexate group compared with methotrexate group. The activities of catalase in the methotrexate group decreased insignificantly although its activities were significantly increased by caffeic acid phenethyl ester administration. The activity of glutathione peroxidase did not change in the groups. There was significant difference in body weight between control and methotrexate-induced groups. In conclusion, the administration of methotrexate causes elevation of oxidative stress although treatment with caffeic acid phenethyl ester has protective effects on the oxidative stress in testes. |
| doi_str_mv | 10.1177/0960327108092293 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_19410066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0960327108092293</sage_id><sourcerecordid>19410066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-b45af5ce44bcb690c943047410e8e573f3816eaf599e8ef0350456a52ca351463</originalsourceid><addsrcrecordid>eNp1kMtrGzEQh0VJqN20956KCLS3TUav1eoYTB-BQC7JMSyydtTI7MORdovz30eLTQ2GnIRmvt-DIeQrgyvGtL4GU4LgmkEFhnMjPpAlk1oXYECckeW8Lub9gnxKaQMApVHsI1mwquJGC1iSp5X1HoOj1oWGbp-xx_H5taWYRoy0G5qptSMm2uXxMEbc5V8R-mZy2NBhFxo7hn9IU16lRENPx1mZ6OBptONncu5tm_DL4b0gj79-Pqz-FHf3v29XN3eFk6Uai7VU1iuHUq7dujTgjBQgtWSAFSotvKhYiRkxJg88CAVSlVZxZ4VishQX5MfedxuHlyk3qLuQHLat7XGYUs1M9oJyBi9PwM0wxT53qzmHSudQnSHYQy4OKUX09TaGzsbXmkE9370-vXuWfDv4TusOm6PgcOgMfD8ANjnb-mh7F9J_joNWSvI5u9hzyf7FY7l3g98Aw76Wug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220874747</pqid></control><display><type>article</type><title>Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat</title><source>Sage Journals GOLD Open Access 2024</source><creator>Armagan, A ; Uzar, E ; Uz, E ; Yilmaz, HR ; Kutluhan, S ; Koyuncuoglu, HR ; Soyupek, S ; Cam, H ; Serel, TA</creator><creatorcontrib>Armagan, A ; Uzar, E ; Uz, E ; Yilmaz, HR ; Kutluhan, S ; Koyuncuoglu, HR ; Soyupek, S ; Cam, H ; Serel, TA</creatorcontrib><description>The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-treated. In the second day of experiment, a single dose of methotrexate was intraperitoneally administered to groups II and III, although a daily single dose of caffeic acid phenethyl ester was intraperitoneally administered to group III for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. In the tissue, the level of lipid peroxidation as malondialdehyde and activities of superoxide dismutase were higher in the methotrexate group than in the control group. Lipid peroxidation levels and superoxide dismutase activities were decreased in caffeic acid phenethyl ester + methotrexate group compared with methotrexate group. The activities of catalase in the methotrexate group decreased insignificantly although its activities were significantly increased by caffeic acid phenethyl ester administration. The activity of glutathione peroxidase did not change in the groups. There was significant difference in body weight between control and methotrexate-induced groups. In conclusion, the administration of methotrexate causes elevation of oxidative stress although treatment with caffeic acid phenethyl ester has protective effects on the oxidative stress in testes.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327108092293</identifier><identifier>PMID: 18829730</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antimetabolites, Antineoplastic - toxicity ; Antioxidants ; Biological and medical sciences ; Body Weight - drug effects ; Caffeic Acids - pharmacology ; Chemotherapy ; Cytotoxins - pharmacology ; Drug Antagonism ; Drug toxicity and drugs side effects treatment ; Enzymes ; Injections, Intraperitoneal ; Lipid Peroxidation - drug effects ; Male ; Males ; Malondialdehyde ; Medical sciences ; Methotrexate - toxicity ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Organ Size - drug effects ; Oxidation ; Oxidative Stress - drug effects ; Pharmacology. Drug treatments ; Phenylethyl Alcohol - analogs & derivatives ; Phenylethyl Alcohol - pharmacology ; Rats ; Rats, Wistar ; Rodents ; Side effects ; Superoxide Dismutase - metabolism ; Testis - drug effects ; Testis - metabolism ; Testis - pathology ; Toxicology ; Urogenital system</subject><ispartof>Human & experimental toxicology, 2008-07, Vol.27 (7), p.547-552</ispartof><rights>2008 INIST-CNRS</rights><rights>SAGE Publications © Jul 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-b45af5ce44bcb690c943047410e8e573f3816eaf599e8ef0350456a52ca351463</citedby><cites>FETCH-LOGICAL-c465t-b45af5ce44bcb690c943047410e8e573f3816eaf599e8ef0350456a52ca351463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327108092293$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327108092293$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327108092293?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20755427$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18829730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armagan, A</creatorcontrib><creatorcontrib>Uzar, E</creatorcontrib><creatorcontrib>Uz, E</creatorcontrib><creatorcontrib>Yilmaz, HR</creatorcontrib><creatorcontrib>Kutluhan, S</creatorcontrib><creatorcontrib>Koyuncuoglu, HR</creatorcontrib><creatorcontrib>Soyupek, S</creatorcontrib><creatorcontrib>Cam, H</creatorcontrib><creatorcontrib>Serel, TA</creatorcontrib><title>Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-treated. In the second day of experiment, a single dose of methotrexate was intraperitoneally administered to groups II and III, although a daily single dose of caffeic acid phenethyl ester was intraperitoneally administered to group III for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. In the tissue, the level of lipid peroxidation as malondialdehyde and activities of superoxide dismutase were higher in the methotrexate group than in the control group. Lipid peroxidation levels and superoxide dismutase activities were decreased in caffeic acid phenethyl ester + methotrexate group compared with methotrexate group. The activities of catalase in the methotrexate group decreased insignificantly although its activities were significantly increased by caffeic acid phenethyl ester administration. The activity of glutathione peroxidase did not change in the groups. There was significant difference in body weight between control and methotrexate-induced groups. In conclusion, the administration of methotrexate causes elevation of oxidative stress although treatment with caffeic acid phenethyl ester has protective effects on the oxidative stress in testes.</description><subject>Animals</subject><subject>Antimetabolites, Antineoplastic - toxicity</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Caffeic Acids - pharmacology</subject><subject>Chemotherapy</subject><subject>Cytotoxins - pharmacology</subject><subject>Drug Antagonism</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Enzymes</subject><subject>Injections, Intraperitoneal</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Males</subject><subject>Malondialdehyde</subject><subject>Medical sciences</subject><subject>Methotrexate - toxicity</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Organ Size - drug effects</subject><subject>Oxidation</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylethyl Alcohol - analogs & derivatives</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Side effects</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Toxicology</subject><subject>Urogenital system</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtrGzEQh0VJqN20956KCLS3TUav1eoYTB-BQC7JMSyydtTI7MORdovz30eLTQ2GnIRmvt-DIeQrgyvGtL4GU4LgmkEFhnMjPpAlk1oXYECckeW8Lub9gnxKaQMApVHsI1mwquJGC1iSp5X1HoOj1oWGbp-xx_H5taWYRoy0G5qptSMm2uXxMEbc5V8R-mZy2NBhFxo7hn9IU16lRENPx1mZ6OBptONncu5tm_DL4b0gj79-Pqz-FHf3v29XN3eFk6Uai7VU1iuHUq7dujTgjBQgtWSAFSotvKhYiRkxJg88CAVSlVZxZ4VishQX5MfedxuHlyk3qLuQHLat7XGYUs1M9oJyBi9PwM0wxT53qzmHSudQnSHYQy4OKUX09TaGzsbXmkE9370-vXuWfDv4TusOm6PgcOgMfD8ANjnb-mh7F9J_joNWSvI5u9hzyf7FY7l3g98Aw76Wug</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Armagan, A</creator><creator>Uzar, E</creator><creator>Uz, E</creator><creator>Yilmaz, HR</creator><creator>Kutluhan, S</creator><creator>Koyuncuoglu, HR</creator><creator>Soyupek, S</creator><creator>Cam, H</creator><creator>Serel, TA</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope></search><sort><creationdate>20080701</creationdate><title>Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat</title><author>Armagan, A ; Uzar, E ; Uz, E ; Yilmaz, HR ; Kutluhan, S ; Koyuncuoglu, HR ; Soyupek, S ; Cam, H ; Serel, TA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-b45af5ce44bcb690c943047410e8e573f3816eaf599e8ef0350456a52ca351463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antimetabolites, Antineoplastic - toxicity</topic><topic>Antioxidants</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Caffeic Acids - pharmacology</topic><topic>Chemotherapy</topic><topic>Cytotoxins - pharmacology</topic><topic>Drug Antagonism</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Enzymes</topic><topic>Injections, Intraperitoneal</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Males</topic><topic>Malondialdehyde</topic><topic>Medical sciences</topic><topic>Methotrexate - toxicity</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Organ Size - drug effects</topic><topic>Oxidation</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylethyl Alcohol - analogs & derivatives</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Side effects</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Toxicology</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armagan, A</creatorcontrib><creatorcontrib>Uzar, E</creatorcontrib><creatorcontrib>Uz, E</creatorcontrib><creatorcontrib>Yilmaz, HR</creatorcontrib><creatorcontrib>Kutluhan, S</creatorcontrib><creatorcontrib>Koyuncuoglu, HR</creatorcontrib><creatorcontrib>Soyupek, S</creatorcontrib><creatorcontrib>Cam, H</creatorcontrib><creatorcontrib>Serel, TA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Armagan, A</au><au>Uzar, E</au><au>Uz, E</au><au>Yilmaz, HR</au><au>Kutluhan, S</au><au>Koyuncuoglu, HR</au><au>Soyupek, S</au><au>Cam, H</au><au>Serel, TA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>27</volume><issue>7</issue><spage>547</spage><epage>552</epage><pages>547-552</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>The aim of this study was to investigate the possible protective role of caffeic acid phenethyl ester on testicular toxicity of methotrexate in rats. Nineteen male rats were divided into three groups as follows: group I, control; group II, methotrexate-treated; group III, methotrexate + caffeic acid phenethyl ester-treated. In the second day of experiment, a single dose of methotrexate was intraperitoneally administered to groups II and III, although a daily single dose of caffeic acid phenethyl ester was intraperitoneally administered to group III for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. In the tissue, the level of lipid peroxidation as malondialdehyde and activities of superoxide dismutase were higher in the methotrexate group than in the control group. Lipid peroxidation levels and superoxide dismutase activities were decreased in caffeic acid phenethyl ester + methotrexate group compared with methotrexate group. The activities of catalase in the methotrexate group decreased insignificantly although its activities were significantly increased by caffeic acid phenethyl ester administration. The activity of glutathione peroxidase did not change in the groups. There was significant difference in body weight between control and methotrexate-induced groups. In conclusion, the administration of methotrexate causes elevation of oxidative stress although treatment with caffeic acid phenethyl ester has protective effects on the oxidative stress in testes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>18829730</pmid><doi>10.1177/0960327108092293</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0960-3271 |
| ispartof | Human & experimental toxicology, 2008-07, Vol.27 (7), p.547-552 |
| issn | 0960-3271 1477-0903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19410066 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Antimetabolites, Antineoplastic - toxicity Antioxidants Biological and medical sciences Body Weight - drug effects Caffeic Acids - pharmacology Chemotherapy Cytotoxins - pharmacology Drug Antagonism Drug toxicity and drugs side effects treatment Enzymes Injections, Intraperitoneal Lipid Peroxidation - drug effects Male Males Malondialdehyde Medical sciences Methotrexate - toxicity Miscellaneous (drug allergy, mutagens, teratogens...) Organ Size - drug effects Oxidation Oxidative Stress - drug effects Pharmacology. Drug treatments Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Rats Rats, Wistar Rodents Side effects Superoxide Dismutase - metabolism Testis - drug effects Testis - metabolism Testis - pathology Toxicology Urogenital system |
| title | Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T14%3A05%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Caffeic%20acid%20phenethyl%20ester%20modulates%20methotrexate-induced%20oxidative%20stress%20in%20testes%20of%20rat&rft.jtitle=Human%20&%20experimental%20toxicology&rft.au=Armagan,%20A&rft.date=2008-07-01&rft.volume=27&rft.issue=7&rft.spage=547&rft.epage=552&rft.pages=547-552&rft.issn=0960-3271&rft.eissn=1477-0903&rft_id=info:doi/10.1177/0960327108092293&rft_dat=%3Cproquest_AFRWT%3E19410066%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220874747&rft_id=info:pmid/18829730&rft_sage_id=10.1177_0960327108092293&rfr_iscdi=true |