Effects of Sulphasalazine in Cerebral Ischemia Reperfusion Injury in Rat

Management of cerebral ischemia/reperfusion (I/R) injury is still difficult process today. Aim of present study was to investigate therapeutic properties of sulfasalazine in cerebral transient I/R injury in rat. Except Control group (n = 5), 20 Wistar albino rats were allocated for acute and chronic...

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Veröffentlicht in:	Archives of medical research 2017-04, Vol.48 (3), p.247-256
Hauptverfasser:	Cetin, Cansel, Erdogan, Ahmet Melih, Dincel, Gungor Cagdas, Bakar, Bulent, Kisa, Ucler
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antiinflamatory Brain Edema - drug therapy Brain Edema - metabolism Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - pathology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebral hypoxia reperfusion injury Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Interleukin-1beta - metabolism Interleukin-6 - metabolism Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Nitric Oxide - metabolism Peroxidase - metabolism Rats, Wistar Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Stroke Sulfasalazine Sulfasalazine - therapeutic use Tumor Necrosis Factor-alpha - metabolism
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