SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p

The class III deacetylase sirtuin 1 (SIRT1), a member of the sirtuin family proteins, plays a key role in many types of cancers including colorectal cancer (CRC). Here we report that SIRT1 suppressed CRC metastasis in vitro and in vivo as a negative regulator for miR-15b-5p transcription. Mechanisti...

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Veröffentlicht in:	Cancer letters 2017-11, Vol.409, p.104-115
Hauptverfasser:	Sun, Li-Na, Zhi, Zheng, Chen, Liang-Yan, Zhou, Qun, Li, Xiu-Ming, Gan, Wen-Juan, Chen, Shu, Yang, Meng, Liu, Yao, Shen, Tong, Xu, Yong, Li, Jian-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxyacyl CoA Dehydrogenases - metabolism Acetyl-CoA C-Acyltransferase - metabolism Activator protein 1 Acyl-CoA oxidase Animals Apoptosis Breast cancer Caco-2 Cells Cancer metastasis Carbon-Carbon Double Bond Isomerases - metabolism Cell Line, Tumor Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Deacetylation Enoyl-CoA Hydratase - metabolism Experiments Fatty-acid oxidation Gene silencing HCT116 Cells Heterografts HT29 Cells Humans Lung cancer Metabolism Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude microRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Metastasis Oxidation Proteins Racemases and Epimerases - metabolism Rodents Signal Transduction SIRT1 SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Transcription factors Transcription, Genetic Transfection Tumors Xenografts
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