Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling

Coactosin-like protein (CLP, or Cotl1), is an F-actin-binding protein, whose role in cancer is largely unknown. Here we show that CLP/Cotl1 is highly expressed in a rat epithelial breast cancer cell line (FE1.3) compared with its mesenchymal counterpart (FE1.2). Knockdown of CLP/Cotl1 in FE1.3 cells...

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Veröffentlicht in:	Oncogene 2018-01, Vol.37 (3), p.323-331
Hauptverfasser:	Xia, L, Xiao, X, Liu, W L, Song, Y, Liu, T J J, Li, Y J, Zacksenhaus, E, Hao, X J, Ben-David, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 13/109 45/61 631/67/1347 631/80/86/2368 64/60 96/109 96/21 Animals Apoptosis Breast Neoplasms - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cyclin-Dependent Kinase Inhibitor p21 - metabolism Female Gene Knockdown Techniques Genes, Tumor Suppressor HEK293 Cells Human Genetics Humans Interleukins - metabolism Internal Medicine MAP Kinase Signaling System MCF-7 Cells Medicine Medicine & Public Health Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, SCID Microfilament Proteins - genetics Microfilament Proteins - metabolism Oncology original-article Rats RNA, Small Interfering - metabolism Transforming Growth Factor beta1 - metabolism Xenograft Model Antitumor Assays
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