Depression and Cognitive Function in Mild Cognitive Impairment: A 1-Year Follow-Up Study
Background: The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in dep...
Gespeichert in:
| Veröffentlicht in: | Journal of geriatric psychiatry and neurology 2017-09, Vol.30 (5), p.280-288 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 288 |
|---|---|
| container_issue | 5 |
| container_start_page | 280 |
| container_title | Journal of geriatric psychiatry and neurology |
| container_volume | 30 |
| creator | Yoon, Seoyoung Shin, Cheolmin Han, Changsu |
| description | Background:
The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in depression symptoms affect cognition longitudinally.
Methods:
For the study, 161 patients with MCI were divided into a depressed group (D+) and a nondepressed group (D−). After 1 year, we redivided the original D− group into D− and newly developed depression (Dd) groups and the D+ group into improved depression (Di) and nonimproved depression (Dn) groups. Neuropsychological tests assessing depression and cognitive domains were performed at baseline and follow-up.
Results:
When age-adjusted, the D+ group showed significantly poorer performance in general cognition and some subtests regarding memory, executive function, and attention. At the 1-year follow-up, changes in the calculation test (P = .005) and Controlled Oral Word Test (COWAT; P = .048) were significantly different between groups. Only the Di group showed significant improvement in calculation. The Dn group showed significant decrement in COWAT that was significantly different from that of the Di group, which showed no significant change.
Discussion:
Patients with depression having MCI showed poorer cognitive function than nondepressed patients with MCI in some cognitive domains. Improvement in depression was related to improvement or prevention of decline in cognitive measures. |
| doi_str_mv | 10.1177/0891988717723741 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1940596183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0891988717723741</sage_id><sourcerecordid>1940596183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-43573b9ed59a646c6926bd1a8c1418d8483daadc562a3c907af885b502980a163</originalsourceid><addsrcrecordid>eNp1kMFLwzAUxoMobk7vnqRHL9GkaZrE25hOBxMPOtBTyZJsZLRJTVpl_70tmyKCp_d43-998H0AnGN0hTFj14gLLDhn3Z4SluEDMMSUppAyxA_BsJdhrw_ASYwbhBAVnByDQcpFSgkhQ_B6a-pgYrTeJdLpZOLXzjb2wyTT1qmmP1uXPNrytzSramlDZVxzk4wTDN-MDMnUl6X_hIs6eW5avT0FRytZRnO2nyOwmN69TB7g_Ol-NhnPoSKENTAjlJGlMJoKmWe5ykWaLzWWXOEMc80zTrSUWtE8lUQJxOSKc7qkKBUcSZyTEbjc-dbBv7cmNkVlozJlKZ3xbSywyLrUOeakQ9EOVcHHGMyqqIOtZNgWGBV9n8XfPruXi717u6yM_nn4LrAD4A6Icm2KjW-D69L-b_gF-9p7eQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1940596183</pqid></control><display><type>article</type><title>Depression and Cognitive Function in Mild Cognitive Impairment: A 1-Year Follow-Up Study</title><source>MEDLINE</source><source>SAGE Journals</source><creator>Yoon, Seoyoung ; Shin, Cheolmin ; Han, Changsu</creator><creatorcontrib>Yoon, Seoyoung ; Shin, Cheolmin ; Han, Changsu</creatorcontrib><description>Background:
The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in depression symptoms affect cognition longitudinally.
Methods:
For the study, 161 patients with MCI were divided into a depressed group (D+) and a nondepressed group (D−). After 1 year, we redivided the original D− group into D− and newly developed depression (Dd) groups and the D+ group into improved depression (Di) and nonimproved depression (Dn) groups. Neuropsychological tests assessing depression and cognitive domains were performed at baseline and follow-up.
Results:
When age-adjusted, the D+ group showed significantly poorer performance in general cognition and some subtests regarding memory, executive function, and attention. At the 1-year follow-up, changes in the calculation test (P = .005) and Controlled Oral Word Test (COWAT; P = .048) were significantly different between groups. Only the Di group showed significant improvement in calculation. The Dn group showed significant decrement in COWAT that was significantly different from that of the Di group, which showed no significant change.
Discussion:
Patients with depression having MCI showed poorer cognitive function than nondepressed patients with MCI in some cognitive domains. Improvement in depression was related to improvement or prevention of decline in cognitive measures.</description><identifier>ISSN: 0891-9887</identifier><identifier>EISSN: 1552-5708</identifier><identifier>DOI: 10.1177/0891988717723741</identifier><identifier>PMID: 28925333</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Cognitive Dysfunction - psychology ; Depressive Disorder - psychology ; Female ; Follow-Up Studies ; Humans ; Male ; Neuropsychological Tests - standards ; Time Factors</subject><ispartof>Journal of geriatric psychiatry and neurology, 2017-09, Vol.30 (5), p.280-288</ispartof><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-43573b9ed59a646c6926bd1a8c1418d8483daadc562a3c907af885b502980a163</citedby><cites>FETCH-LOGICAL-c337t-43573b9ed59a646c6926bd1a8c1418d8483daadc562a3c907af885b502980a163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0891988717723741$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0891988717723741$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28925333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Seoyoung</creatorcontrib><creatorcontrib>Shin, Cheolmin</creatorcontrib><creatorcontrib>Han, Changsu</creatorcontrib><title>Depression and Cognitive Function in Mild Cognitive Impairment: A 1-Year Follow-Up Study</title><title>Journal of geriatric psychiatry and neurology</title><addtitle>J Geriatr Psychiatry Neurol</addtitle><description>Background:
The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in depression symptoms affect cognition longitudinally.
Methods:
For the study, 161 patients with MCI were divided into a depressed group (D+) and a nondepressed group (D−). After 1 year, we redivided the original D− group into D− and newly developed depression (Dd) groups and the D+ group into improved depression (Di) and nonimproved depression (Dn) groups. Neuropsychological tests assessing depression and cognitive domains were performed at baseline and follow-up.
Results:
When age-adjusted, the D+ group showed significantly poorer performance in general cognition and some subtests regarding memory, executive function, and attention. At the 1-year follow-up, changes in the calculation test (P = .005) and Controlled Oral Word Test (COWAT; P = .048) were significantly different between groups. Only the Di group showed significant improvement in calculation. The Dn group showed significant decrement in COWAT that was significantly different from that of the Di group, which showed no significant change.
Discussion:
Patients with depression having MCI showed poorer cognitive function than nondepressed patients with MCI in some cognitive domains. Improvement in depression was related to improvement or prevention of decline in cognitive measures.</description><subject>Aged</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Neuropsychological Tests - standards</subject><subject>Time Factors</subject><issn>0891-9887</issn><issn>1552-5708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFLwzAUxoMobk7vnqRHL9GkaZrE25hOBxMPOtBTyZJsZLRJTVpl_70tmyKCp_d43-998H0AnGN0hTFj14gLLDhn3Z4SluEDMMSUppAyxA_BsJdhrw_ASYwbhBAVnByDQcpFSgkhQ_B6a-pgYrTeJdLpZOLXzjb2wyTT1qmmP1uXPNrytzSramlDZVxzk4wTDN-MDMnUl6X_hIs6eW5avT0FRytZRnO2nyOwmN69TB7g_Ol-NhnPoSKENTAjlJGlMJoKmWe5ykWaLzWWXOEMc80zTrSUWtE8lUQJxOSKc7qkKBUcSZyTEbjc-dbBv7cmNkVlozJlKZ3xbSywyLrUOeakQ9EOVcHHGMyqqIOtZNgWGBV9n8XfPruXi717u6yM_nn4LrAD4A6Icm2KjW-D69L-b_gF-9p7eQ</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Yoon, Seoyoung</creator><creator>Shin, Cheolmin</creator><creator>Han, Changsu</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Depression and Cognitive Function in Mild Cognitive Impairment: A 1-Year Follow-Up Study</title><author>Yoon, Seoyoung ; Shin, Cheolmin ; Han, Changsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-43573b9ed59a646c6926bd1a8c1418d8483daadc562a3c907af885b502980a163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Neuropsychological Tests - standards</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Seoyoung</creatorcontrib><creatorcontrib>Shin, Cheolmin</creatorcontrib><creatorcontrib>Han, Changsu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of geriatric psychiatry and neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Seoyoung</au><au>Shin, Cheolmin</au><au>Han, Changsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression and Cognitive Function in Mild Cognitive Impairment: A 1-Year Follow-Up Study</atitle><jtitle>Journal of geriatric psychiatry and neurology</jtitle><addtitle>J Geriatr Psychiatry Neurol</addtitle><date>2017-09</date><risdate>2017</risdate><volume>30</volume><issue>5</issue><spage>280</spage><epage>288</epage><pages>280-288</pages><issn>0891-9887</issn><eissn>1552-5708</eissn><abstract>Background:
The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in depression symptoms affect cognition longitudinally.
Methods:
For the study, 161 patients with MCI were divided into a depressed group (D+) and a nondepressed group (D−). After 1 year, we redivided the original D− group into D− and newly developed depression (Dd) groups and the D+ group into improved depression (Di) and nonimproved depression (Dn) groups. Neuropsychological tests assessing depression and cognitive domains were performed at baseline and follow-up.
Results:
When age-adjusted, the D+ group showed significantly poorer performance in general cognition and some subtests regarding memory, executive function, and attention. At the 1-year follow-up, changes in the calculation test (P = .005) and Controlled Oral Word Test (COWAT; P = .048) were significantly different between groups. Only the Di group showed significant improvement in calculation. The Dn group showed significant decrement in COWAT that was significantly different from that of the Di group, which showed no significant change.
Discussion:
Patients with depression having MCI showed poorer cognitive function than nondepressed patients with MCI in some cognitive domains. Improvement in depression was related to improvement or prevention of decline in cognitive measures.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28925333</pmid><doi>10.1177/0891988717723741</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0891-9887 |
| ispartof | Journal of geriatric psychiatry and neurology, 2017-09, Vol.30 (5), p.280-288 |
| issn | 0891-9887 1552-5708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1940596183 |
| source | MEDLINE; SAGE Journals |
| subjects | Aged Cognitive Dysfunction - psychology Depressive Disorder - psychology Female Follow-Up Studies Humans Male Neuropsychological Tests - standards Time Factors |
| title | Depression and Cognitive Function in Mild Cognitive Impairment: A 1-Year Follow-Up Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T09%3A44%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Depression%20and%20Cognitive%20Function%20in%20Mild%20Cognitive%20Impairment:%20A%201-Year%20Follow-Up%20Study&rft.jtitle=Journal%20of%20geriatric%20psychiatry%20and%20neurology&rft.au=Yoon,%20Seoyoung&rft.date=2017-09&rft.volume=30&rft.issue=5&rft.spage=280&rft.epage=288&rft.pages=280-288&rft.issn=0891-9887&rft.eissn=1552-5708&rft_id=info:doi/10.1177/0891988717723741&rft_dat=%3Cproquest_cross%3E1940596183%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1940596183&rft_id=info:pmid/28925333&rft_sage_id=10.1177_0891988717723741&rfr_iscdi=true |