Serum vascular endothelial growth factor A levels reflect itch severity in mycosis fungoides and Sézary syndrome
Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)‐A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated wi...
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| Veröffentlicht in: | Journal of dermatology 2018-01, Vol.45 (1), p.95-99 |
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| creator | Sakamoto, Minami Miyagaki, Tomomitsu Kamijo, Hiroaki Oka, Tomonori Takahashi, Naomi Suga, Hiraku Yoshizaki, Ayumi Asano, Yoshihide Sugaya, Makoto Sato, Shinichi |
| description | Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)‐A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF‐A levels in MF/SS patients. Serum VEGF‐A levels were elevated in patients with erythrodermic MF/SS and the levels decreased after treatment. Importantly, serum VEGF‐A levels positively correlated with markers for pruritus. We also found that VEGF‐A upregulated mRNA expression of thymic stromal lymphopoietin by keratinocytes. Taken together, our study suggests that VEGF‐A can promote progression and pruritus in MF/SS. Inhibition of VEGF‐A signaling can be a therapeutic strategy for patients with erythrodermic MF/SS. |
| doi_str_mv | 10.1111/1346-8138.14033 |
| format | Article |
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Vascular endothelial growth factor (VEGF)‐A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF‐A levels in MF/SS patients. Serum VEGF‐A levels were elevated in patients with erythrodermic MF/SS and the levels decreased after treatment. Importantly, serum VEGF‐A levels positively correlated with markers for pruritus. We also found that VEGF‐A upregulated mRNA expression of thymic stromal lymphopoietin by keratinocytes. Taken together, our study suggests that VEGF‐A can promote progression and pruritus in MF/SS. Inhibition of VEGF‐A signaling can be a therapeutic strategy for patients with erythrodermic MF/SS.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.14033</identifier><identifier>PMID: 28925057</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Angiogenesis ; Case-Control Studies ; Cell Line ; cutaneous T‐cell lymphoma ; Cytokines - metabolism ; epidermal keratinocytes ; Female ; Fungal infections ; Gene expression ; Humans ; Keratinocytes ; Keratinocytes - metabolism ; Male ; Middle Aged ; Mycosis ; Mycosis fungoides ; Mycosis Fungoides - blood ; Mycosis Fungoides - complications ; Pruritus ; Pruritus - blood ; Pruritus - etiology ; Sezary Syndrome - blood ; Sezary Syndrome - complications ; Skin diseases ; Thymic stromal lymphopoietin ; Thymus ; Tumor cells ; Vascular endothelial growth factor ; vascular endothelial growth factor A ; Vascular Endothelial Growth Factor A - blood ; Vascular Endothelial Growth Factor C - blood</subject><ispartof>Journal of dermatology, 2018-01, Vol.45 (1), p.95-99</ispartof><rights>2017 Japanese Dermatological Association</rights><rights>2017 Japanese Dermatological Association.</rights><rights>Copyright © 2018 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4613-d62b36a709cdd6f6ac7ceb807f1056416869b7a45f19934d542ef5ff6315ebaa3</citedby><cites>FETCH-LOGICAL-c4613-d62b36a709cdd6f6ac7ceb807f1056416869b7a45f19934d542ef5ff6315ebaa3</cites><orcidid>0000-0003-1879-3128 ; 0000-0002-1618-329X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.14033$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.14033$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28925057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakamoto, Minami</creatorcontrib><creatorcontrib>Miyagaki, Tomomitsu</creatorcontrib><creatorcontrib>Kamijo, Hiroaki</creatorcontrib><creatorcontrib>Oka, Tomonori</creatorcontrib><creatorcontrib>Takahashi, Naomi</creatorcontrib><creatorcontrib>Suga, Hiraku</creatorcontrib><creatorcontrib>Yoshizaki, Ayumi</creatorcontrib><creatorcontrib>Asano, Yoshihide</creatorcontrib><creatorcontrib>Sugaya, Makoto</creatorcontrib><creatorcontrib>Sato, Shinichi</creatorcontrib><title>Serum vascular endothelial growth factor A levels reflect itch severity in mycosis fungoides and Sézary syndrome</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)‐A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF‐A levels in MF/SS patients. Serum VEGF‐A levels were elevated in patients with erythrodermic MF/SS and the levels decreased after treatment. Importantly, serum VEGF‐A levels positively correlated with markers for pruritus. We also found that VEGF‐A upregulated mRNA expression of thymic stromal lymphopoietin by keratinocytes. Taken together, our study suggests that VEGF‐A can promote progression and pruritus in MF/SS. Inhibition of VEGF‐A signaling can be a therapeutic strategy for patients with erythrodermic MF/SS.</description><subject>Aged</subject><subject>Angiogenesis</subject><subject>Case-Control Studies</subject><subject>Cell Line</subject><subject>cutaneous T‐cell lymphoma</subject><subject>Cytokines - metabolism</subject><subject>epidermal keratinocytes</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Keratinocytes</subject><subject>Keratinocytes - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycosis</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - blood</subject><subject>Mycosis Fungoides - complications</subject><subject>Pruritus</subject><subject>Pruritus - blood</subject><subject>Pruritus - etiology</subject><subject>Sezary Syndrome - blood</subject><subject>Sezary Syndrome - complications</subject><subject>Skin diseases</subject><subject>Thymic stromal lymphopoietin</subject><subject>Thymus</subject><subject>Tumor cells</subject><subject>Vascular endothelial growth factor</subject><subject>vascular endothelial growth factor A</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vascular Endothelial Growth Factor C - blood</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCmh2yxIZNWjv-SbysSsuPKrEorC3HHve6cuLWTlqFN-I5-mL4cksXbJjNSEffHM2cQegtJUe01jFlXDY9Zf0R5YSxZ2jzpDxHG8J60bScdAfoVSnXhLRKUPISHbS9agUR3QbdXkJeRnxnil2iyRgml-YtxGAivsrpft5ib-ycMj7BEe4gFpzBR7AzDrPd4lK1HOYVhwmPq00lFOyX6SoFBwWbyeHLh18_TV5xWSeX0wiv0QtvYoE3j_0Q_Tg_-376ubn49unL6clFY7mkrHGyHZg0HVHWOemlsZ2FoSedp0RITmUv1dAZLjxVinEneAteeC8ZFTAYww7Rh73vTU63C5RZj6FYiNFMkJaiqeJEKK4Eqej7f9DrtOSpblepnjPeyY5W6nhP2ZxKqSnomxzGepqmRO--oXfZ6132-s836sS7R99lGME98X_jr4DYA_chwvo_P_3149ne-Del55WN</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Sakamoto, Minami</creator><creator>Miyagaki, Tomomitsu</creator><creator>Kamijo, Hiroaki</creator><creator>Oka, Tomonori</creator><creator>Takahashi, Naomi</creator><creator>Suga, Hiraku</creator><creator>Yoshizaki, Ayumi</creator><creator>Asano, Yoshihide</creator><creator>Sugaya, Makoto</creator><creator>Sato, Shinichi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1879-3128</orcidid><orcidid>https://orcid.org/0000-0002-1618-329X</orcidid></search><sort><creationdate>201801</creationdate><title>Serum vascular endothelial growth factor A levels reflect itch severity in mycosis fungoides and Sézary syndrome</title><author>Sakamoto, Minami ; Miyagaki, Tomomitsu ; Kamijo, Hiroaki ; Oka, Tomonori ; Takahashi, Naomi ; Suga, Hiraku ; Yoshizaki, Ayumi ; Asano, Yoshihide ; Sugaya, Makoto ; Sato, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4613-d62b36a709cdd6f6ac7ceb807f1056416869b7a45f19934d542ef5ff6315ebaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Angiogenesis</topic><topic>Case-Control Studies</topic><topic>Cell Line</topic><topic>cutaneous T‐cell lymphoma</topic><topic>Cytokines - metabolism</topic><topic>epidermal keratinocytes</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Keratinocytes</topic><topic>Keratinocytes - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycosis</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - blood</topic><topic>Mycosis Fungoides - complications</topic><topic>Pruritus</topic><topic>Pruritus - blood</topic><topic>Pruritus - etiology</topic><topic>Sezary Syndrome - blood</topic><topic>Sezary Syndrome - complications</topic><topic>Skin diseases</topic><topic>Thymic stromal lymphopoietin</topic><topic>Thymus</topic><topic>Tumor cells</topic><topic>Vascular endothelial growth factor</topic><topic>vascular endothelial growth factor A</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vascular Endothelial Growth Factor C - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakamoto, Minami</creatorcontrib><creatorcontrib>Miyagaki, Tomomitsu</creatorcontrib><creatorcontrib>Kamijo, Hiroaki</creatorcontrib><creatorcontrib>Oka, Tomonori</creatorcontrib><creatorcontrib>Takahashi, Naomi</creatorcontrib><creatorcontrib>Suga, Hiraku</creatorcontrib><creatorcontrib>Yoshizaki, Ayumi</creatorcontrib><creatorcontrib>Asano, Yoshihide</creatorcontrib><creatorcontrib>Sugaya, Makoto</creatorcontrib><creatorcontrib>Sato, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakamoto, Minami</au><au>Miyagaki, Tomomitsu</au><au>Kamijo, Hiroaki</au><au>Oka, Tomonori</au><au>Takahashi, Naomi</au><au>Suga, Hiraku</au><au>Yoshizaki, Ayumi</au><au>Asano, Yoshihide</au><au>Sugaya, Makoto</au><au>Sato, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum vascular endothelial growth factor A levels reflect itch severity in mycosis fungoides and Sézary syndrome</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>45</volume><issue>1</issue><spage>95</spage><epage>99</epage><pages>95-99</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)‐A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF‐A levels in MF/SS patients. Serum VEGF‐A levels were elevated in patients with erythrodermic MF/SS and the levels decreased after treatment. Importantly, serum VEGF‐A levels positively correlated with markers for pruritus. We also found that VEGF‐A upregulated mRNA expression of thymic stromal lymphopoietin by keratinocytes. Taken together, our study suggests that VEGF‐A can promote progression and pruritus in MF/SS. Inhibition of VEGF‐A signaling can be a therapeutic strategy for patients with erythrodermic MF/SS.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28925057</pmid><doi>10.1111/1346-8138.14033</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1879-3128</orcidid><orcidid>https://orcid.org/0000-0002-1618-329X</orcidid></addata></record> |
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| subjects | Aged Angiogenesis Case-Control Studies Cell Line cutaneous T‐cell lymphoma Cytokines - metabolism epidermal keratinocytes Female Fungal infections Gene expression Humans Keratinocytes Keratinocytes - metabolism Male Middle Aged Mycosis Mycosis fungoides Mycosis Fungoides - blood Mycosis Fungoides - complications Pruritus Pruritus - blood Pruritus - etiology Sezary Syndrome - blood Sezary Syndrome - complications Skin diseases Thymic stromal lymphopoietin Thymus Tumor cells Vascular endothelial growth factor vascular endothelial growth factor A Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor C - blood |
| title | Serum vascular endothelial growth factor A levels reflect itch severity in mycosis fungoides and Sézary syndrome |
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