BMP7-induced-Pten inhibits Akt and prevents renal fibrosis

Bone morphogenetic protein-7 (BMP-7) counteracts pro-fibrotic effects of TGFβ1 in cultured renal cells and protects from fibrosis in acute and chronic renal injury models. Using the unilateral ureteral obstruction (UUO) model of chronic renal fibrosis, we investigated the effect of exogenous-rhBMP-7...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2017-12, Vol.1863 (12), p.3095-3104
Hauptverfasser:	Higgins, Debra F., Ewart, Leah M., Masterson, Enda, Tennant, Sadhbh, Grebnev, Gleb, Prunotto, Marco, Pomposiello, Sylvia, Conde-Knape, Karin, Martin, Finian M., Godson, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Anti-fibrotic Bone Morphogenetic Protein 7 - metabolism Bone Morphogenetic Protein 7 - pharmacology Cell Hypoxia - physiology Cell Line Collagen - metabolism Disease Models, Animal Fibrosis Fibrosis - enzymology Fibrosis - pathology Fibrosis - prevention & control Hypoxia Kidney Diseases - enzymology Kidney Diseases - pathology Kidney Diseases - prevention & control Kidney Tubules - drug effects Kidney Tubules - pathology Mice Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN Phosphohydrolase - biosynthesis PTEN Phosphohydrolase - metabolism Signal Transduction - drug effects Smad Proteins - metabolism TGFβ1 Transforming Growth Factor beta1 - metabolism Up-Regulation
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