A novel LC-MS/MS method for the quantitative measurement of the acetate content in pharmaceutical peptides

•Pseudo MRM is most suitable for small molecular ions resilient to fragmentation.•Simultaneous analysis of acetate and peptides by switched polarity LC-MS/MS.•Ammonium and formate saturating the ion source don’t impede proteomic analysis.•LC-MS/MS analysis of acetate can corroborate the existing com...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2017-11, Vol.146, p.354-360
Hauptverfasser:	Qasem, Rani J., Farh, Ibrahim K., Al Essa, Mohammed A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetate Acetic Acid - chemistry Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase - methods Drug analysis Mass spectrometry Peptide pharmaceuticals Peptides - chemistry Pharmaceutical Preparations - chemistry Pseudo multiple reaction monitoring Quality Control Reproducibility of Results Tandem Mass Spectrometry - methods Tetracosactide
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