Elastic and inelastic light scattering spectroscopy and its possible use for label-free brain tumor typing
This paper presents an approach for label-free brain tumor tissue typing. For this application, our dual modality microspectroscopy system combines inelastic Raman scattering spectroscopy and Mie elastic light scattering spectroscopy. The system enables marker-free biomedical diagnostics and records...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2017-11, Vol.409 (28), p.6613-6623 |
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| container_issue | 28 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Ostertag, Edwin Stefanakis, Mona Rebner, Karsten Kessler, Rudolf W. |
| description | This paper presents an approach for label-free brain tumor tissue typing. For this application, our dual modality microspectroscopy system combines inelastic Raman scattering spectroscopy and Mie elastic light scattering spectroscopy. The system enables marker-free biomedical diagnostics and records both the chemical and morphologic changes of tissues on a cellular and subcellular level. The system setup is described and the suitability for measuring morphologic features is investigated.
Graphical Abstract
Bimodal approach for label-free brain tumor typing. Elastic and inelastic light scattering spectra are collected laterally resolved in one measurement setup. The spectra are investigated by multivariate data analysis for assigning the tissues to specific WHO grades according to their malignancy |
| doi_str_mv | 10.1007/s00216-017-0614-1 |
| format | Article |
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Graphical Abstract
Bimodal approach for label-free brain tumor typing. Elastic and inelastic light scattering spectra are collected laterally resolved in one measurement setup. The spectra are investigated by multivariate data analysis for assigning the tissues to specific WHO grades according to their malignancy</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-017-0614-1</identifier><identifier>PMID: 28918486</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analytical Chemistry ; Biochemistry ; Brain ; Brain cancer ; Brain tumors ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Diagnosis ; Elastic scattering ; Food Science ; Inelastic scattering ; Laboratory Medicine ; Light scattering ; Monitoring/Environmental Analysis ; Raman spectra ; Research Paper ; Spectroscopy ; Spectrum analysis ; Tissue typing</subject><ispartof>Analytical and bioanalytical chemistry, 2017-11, Vol.409 (28), p.6613-6623</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Analytical and Bioanalytical Chemistry is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-64eca75c82f3db3fe7df4d831723074ecd0f65a8fb1dfa04e6b4c73c65d62c0b3</citedby><cites>FETCH-LOGICAL-c476t-64eca75c82f3db3fe7df4d831723074ecd0f65a8fb1dfa04e6b4c73c65d62c0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-017-0614-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-017-0614-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28918486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ostertag, Edwin</creatorcontrib><creatorcontrib>Stefanakis, Mona</creatorcontrib><creatorcontrib>Rebner, Karsten</creatorcontrib><creatorcontrib>Kessler, Rudolf W.</creatorcontrib><title>Elastic and inelastic light scattering spectroscopy and its possible use for label-free brain tumor typing</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>This paper presents an approach for label-free brain tumor tissue typing. For this application, our dual modality microspectroscopy system combines inelastic Raman scattering spectroscopy and Mie elastic light scattering spectroscopy. The system enables marker-free biomedical diagnostics and records both the chemical and morphologic changes of tissues on a cellular and subcellular level. The system setup is described and the suitability for measuring morphologic features is investigated.
Graphical Abstract
Bimodal approach for label-free brain tumor typing. Elastic and inelastic light scattering spectra are collected laterally resolved in one measurement setup. The spectra are investigated by multivariate data analysis for assigning the tissues to specific WHO grades according to their malignancy</description><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain tumors</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diagnosis</subject><subject>Elastic scattering</subject><subject>Food Science</subject><subject>Inelastic scattering</subject><subject>Laboratory Medicine</subject><subject>Light scattering</subject><subject>Monitoring/Environmental Analysis</subject><subject>Raman spectra</subject><subject>Research Paper</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Tissue 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Graphical Abstract
Bimodal approach for label-free brain tumor typing. Elastic and inelastic light scattering spectra are collected laterally resolved in one measurement setup. The spectra are investigated by multivariate data analysis for assigning the tissues to specific WHO grades according to their malignancy</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28918486</pmid><doi>10.1007/s00216-017-0614-1</doi><tpages>11</tpages></addata></record> |
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| subjects | Analytical Chemistry Biochemistry Brain Brain cancer Brain tumors Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Diagnosis Elastic scattering Food Science Inelastic scattering Laboratory Medicine Light scattering Monitoring/Environmental Analysis Raman spectra Research Paper Spectroscopy Spectrum analysis Tissue typing |
| title | Elastic and inelastic light scattering spectroscopy and its possible use for label-free brain tumor typing |
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