Antibacterial and antitumor activity of Bogorol B-JX isolated from Brevibacillus laterosporus JX-5
Antimicrobial peptides are promising anti-infective agent candidates because they have a broad antimicrobial spectrum and bioactivity and are unlikely to elicit antibiotic resistance. The bogorols represent a new cationic antibiotic peptide and possess great therapeutic potential because of their bi...
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| Veröffentlicht in: | World journal of microbiology & biotechnology 2017-10, Vol.33 (10), p.177-177, Article 177 |
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| creator | Jiang, Hongxia Ji, Chao Sui, Junkang Sa, Rongbo Wang, Xiaohui Liu, Xunli Guo, Tai L. |
| description | Antimicrobial peptides are promising anti-infective agent candidates because they have a broad antimicrobial spectrum and bioactivity and are unlikely to elicit antibiotic resistance. The bogorols represent a new cationic antibiotic peptide and possess great therapeutic potential because of their bioactivity and precise mode of action. Here, we report that Bogorol B-JX (BBJX), a peptide previously isolated from
Brevibacillus laterosporus
JX-5 by us, has significant antibacterial and antitumor activities in vitro. BBJX was found to inhibit methicillin-resistant
Staphylococcus aureus
(MRSA) at 2.5 µg/mL with distinct mechanisms of action from those against
Bacillus bombyseptieus
and
Escherichia coli
. It penetrates MRSA membrane with little visible destruction and binds to genomic DNA. BBJX could inhibit the proliferation of human histiocytic lymphoma cell line U-937 and ConA-activated spleen cells at 5 µg/mL, but was not cytotoxic to the Jurkat cells, resting spleen cells or differentiated macrophage-like U-937 immunocytes. Moreover, BBJX caused apoptosis of U-937 cells by opening the mitochondrial permeability transition pore and stimulating the production of reactive oxygen species. Taken together, these studies provided basis for future medical application of the bogorols. |
| doi_str_mv | 10.1007/s11274-017-2337-z |
| format | Article |
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Brevibacillus laterosporus
JX-5 by us, has significant antibacterial and antitumor activities in vitro. BBJX was found to inhibit methicillin-resistant
Staphylococcus aureus
(MRSA) at 2.5 µg/mL with distinct mechanisms of action from those against
Bacillus bombyseptieus
and
Escherichia coli
. It penetrates MRSA membrane with little visible destruction and binds to genomic DNA. BBJX could inhibit the proliferation of human histiocytic lymphoma cell line U-937 and ConA-activated spleen cells at 5 µg/mL, but was not cytotoxic to the Jurkat cells, resting spleen cells or differentiated macrophage-like U-937 immunocytes. Moreover, BBJX caused apoptosis of U-937 cells by opening the mitochondrial permeability transition pore and stimulating the production of reactive oxygen species. Taken together, these studies provided basis for future medical application of the bogorols.</description><identifier>ISSN: 0959-3993</identifier><identifier>EISSN: 1573-0972</identifier><identifier>DOI: 10.1007/s11274-017-2337-z</identifier><identifier>PMID: 28921048</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Anticancer properties ; Antimicrobial agents ; Antimicrobial peptides ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Apoptosis ; Applied Microbiology ; Bacillus - drug effects ; Bacterial Proteins - isolation & purification ; Bacterial Proteins - pharmacology ; Biochemistry ; Biocompatibility ; Biological activity ; Biomedical and Life Sciences ; Biotechnology ; Brevibacillus - chemistry ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Concanavalin A ; Cytotoxicity ; Deoxyribonucleic acid ; DNA ; Drug resistance ; E coli ; Environmental Engineering/Biotechnology ; Escherichia coli - drug effects ; Histiocytic lymphoma ; Humans ; Jurkat Cells ; Life Sciences ; Lymphoma ; Macrophages ; Membrane permeability ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Sensitivity Tests ; Microbiology ; Mitochondrial DNA ; Mitochondrial permeability transition pore ; Mode of action ; Original Paper ; Peptides ; Peptides - isolation & purification ; Peptides - pharmacology ; Reactive oxygen species ; Spleen ; Staphylococcus aureus ; Staphylococcus infections</subject><ispartof>World journal of microbiology & biotechnology, 2017-10, Vol.33 (10), p.177-177, Article 177</ispartof><rights>Springer Science+Business Media B.V. 2017</rights><rights>World Journal of Microbiology and Biotechnology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-ad09639b1d69540adee70d3dc5993b110c4b81f90c7783035fde6cfa75eac77d3</citedby><cites>FETCH-LOGICAL-c409t-ad09639b1d69540adee70d3dc5993b110c4b81f90c7783035fde6cfa75eac77d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11274-017-2337-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11274-017-2337-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28921048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Hongxia</creatorcontrib><creatorcontrib>Ji, Chao</creatorcontrib><creatorcontrib>Sui, Junkang</creatorcontrib><creatorcontrib>Sa, Rongbo</creatorcontrib><creatorcontrib>Wang, Xiaohui</creatorcontrib><creatorcontrib>Liu, Xunli</creatorcontrib><creatorcontrib>Guo, Tai L.</creatorcontrib><title>Antibacterial and antitumor activity of Bogorol B-JX isolated from Brevibacillus laterosporus JX-5</title><title>World journal of microbiology & biotechnology</title><addtitle>World J Microbiol Biotechnol</addtitle><addtitle>World J Microbiol Biotechnol</addtitle><description>Antimicrobial peptides are promising anti-infective agent candidates because they have a broad antimicrobial spectrum and bioactivity and are unlikely to elicit antibiotic resistance. The bogorols represent a new cationic antibiotic peptide and possess great therapeutic potential because of their bioactivity and precise mode of action. Here, we report that Bogorol B-JX (BBJX), a peptide previously isolated from
Brevibacillus laterosporus
JX-5 by us, has significant antibacterial and antitumor activities in vitro. BBJX was found to inhibit methicillin-resistant
Staphylococcus aureus
(MRSA) at 2.5 µg/mL with distinct mechanisms of action from those against
Bacillus bombyseptieus
and
Escherichia coli
. It penetrates MRSA membrane with little visible destruction and binds to genomic DNA. BBJX could inhibit the proliferation of human histiocytic lymphoma cell line U-937 and ConA-activated spleen cells at 5 µg/mL, but was not cytotoxic to the Jurkat cells, resting spleen cells or differentiated macrophage-like U-937 immunocytes. Moreover, BBJX caused apoptosis of U-937 cells by opening the mitochondrial permeability transition pore and stimulating the production of reactive oxygen species. Taken together, these studies provided basis for future medical application of the bogorols.</description><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Anticancer properties</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial peptides</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Applied Microbiology</subject><subject>Bacillus - drug effects</subject><subject>Bacterial Proteins - isolation & purification</subject><subject>Bacterial Proteins - pharmacology</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Brevibacillus - chemistry</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Concanavalin A</subject><subject>Cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Environmental Engineering/Biotechnology</subject><subject>Escherichia coli - drug effects</subject><subject>Histiocytic lymphoma</subject><subject>Humans</subject><subject>Jurkat Cells</subject><subject>Life Sciences</subject><subject>Lymphoma</subject><subject>Macrophages</subject><subject>Membrane permeability</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Mitochondrial DNA</subject><subject>Mitochondrial permeability transition pore</subject><subject>Mode of action</subject><subject>Original Paper</subject><subject>Peptides</subject><subject>Peptides - 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Academic</collection><jtitle>World journal of microbiology & biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Hongxia</au><au>Ji, Chao</au><au>Sui, Junkang</au><au>Sa, Rongbo</au><au>Wang, Xiaohui</au><au>Liu, Xunli</au><au>Guo, Tai L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial and antitumor activity of Bogorol B-JX isolated from Brevibacillus laterosporus JX-5</atitle><jtitle>World journal of microbiology & biotechnology</jtitle><stitle>World J Microbiol Biotechnol</stitle><addtitle>World J Microbiol Biotechnol</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>33</volume><issue>10</issue><spage>177</spage><epage>177</epage><pages>177-177</pages><artnum>177</artnum><issn>0959-3993</issn><eissn>1573-0972</eissn><abstract>Antimicrobial peptides are promising anti-infective agent candidates because they have a broad antimicrobial spectrum and bioactivity and are unlikely to elicit antibiotic resistance. The bogorols represent a new cationic antibiotic peptide and possess great therapeutic potential because of their bioactivity and precise mode of action. Here, we report that Bogorol B-JX (BBJX), a peptide previously isolated from
Brevibacillus laterosporus
JX-5 by us, has significant antibacterial and antitumor activities in vitro. BBJX was found to inhibit methicillin-resistant
Staphylococcus aureus
(MRSA) at 2.5 µg/mL with distinct mechanisms of action from those against
Bacillus bombyseptieus
and
Escherichia coli
. It penetrates MRSA membrane with little visible destruction and binds to genomic DNA. BBJX could inhibit the proliferation of human histiocytic lymphoma cell line U-937 and ConA-activated spleen cells at 5 µg/mL, but was not cytotoxic to the Jurkat cells, resting spleen cells or differentiated macrophage-like U-937 immunocytes. Moreover, BBJX caused apoptosis of U-937 cells by opening the mitochondrial permeability transition pore and stimulating the production of reactive oxygen species. Taken together, these studies provided basis for future medical application of the bogorols.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>28921048</pmid><doi>10.1007/s11274-017-2337-z</doi><tpages>1</tpages></addata></record> |
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| ispartof | World journal of microbiology & biotechnology, 2017-10, Vol.33 (10), p.177-177, Article 177 |
| issn | 0959-3993 1573-0972 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Anticancer properties Antimicrobial agents Antimicrobial peptides Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Applied Microbiology Bacillus - drug effects Bacterial Proteins - isolation & purification Bacterial Proteins - pharmacology Biochemistry Biocompatibility Biological activity Biomedical and Life Sciences Biotechnology Brevibacillus - chemistry Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Concanavalin A Cytotoxicity Deoxyribonucleic acid DNA Drug resistance E coli Environmental Engineering/Biotechnology Escherichia coli - drug effects Histiocytic lymphoma Humans Jurkat Cells Life Sciences Lymphoma Macrophages Membrane permeability Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Microbiology Mitochondrial DNA Mitochondrial permeability transition pore Mode of action Original Paper Peptides Peptides - isolation & purification Peptides - pharmacology Reactive oxygen species Spleen Staphylococcus aureus Staphylococcus infections |
| title | Antibacterial and antitumor activity of Bogorol B-JX isolated from Brevibacillus laterosporus JX-5 |
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