Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction

Chronic hyperglycemia aggravates insulin resistance, in part due to increased formation of advanced glycation end-products (AGEs). Methylglyoxal (MG), a major precursor of AGEs, accumulates abnormally in various tissues and organs and participates in oxidative damage. We investigated the insulinotro...

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Veröffentlicht in:	Chemico-biological interactions 2017-11, Vol.277, p.101-109
Hauptverfasser:	Suh, Kwang Sik, Chon, Suk, Jung, Woon-Won, Choi, Eun Mi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biphenyl Compounds - chemistry Biphenyl Compounds - isolation & purification Biphenyl Compounds - pharmacology Cell Death - drug effects Cell Line Cell Survival - drug effects Cytoprotection - drug effects Insulin - metabolism Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Magnolia - chemistry Magnolol Methylglyoxal Mitochondrial biogenesis Oxidative stress Pancreatic beta cells Protective Agents - chemistry Protective Agents - isolation & purification Protective Agents - pharmacology Pyruvaldehyde - metabolism Rats
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