Prediction of motor recovery after stroke: advances in biomarkers
Stroke remains a leading cause of adult disability, and the recovery of motor function after stroke is crucial for the patient to regain independence. However, making accurate predictions of a patient's motor recovery and outcome is difficult when based on clinical assessment alone. Clinical as...
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| Veröffentlicht in: | Lancet neurology 2017-10, Vol.16 (10), p.826-836 |
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| container_title | Lancet neurology |
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| creator | Stinear, Cathy M |
| description | Stroke remains a leading cause of adult disability, and the recovery of motor function after stroke is crucial for the patient to regain independence. However, making accurate predictions of a patient's motor recovery and outcome is difficult when based on clinical assessment alone. Clinical assessment of motor impairment within a few days of stroke can help to predict subsequent recovery, while neurophysiological and neuroimaging biomarkers of corticomotor structure and function can help to predict both motor recovery and motor outcome after stroke. The combination of biomarkers can provide clinically useful information when planning the personalised rehabilitation of a patient. These biomarkers can also be used for patient selection and stratification in trials investigating rehabilitation interventions that are initiated early after stroke. Ongoing multicentre trials that incorporate motor biomarkers could help to bring their use into routine clinical practice. |
| doi_str_mv | 10.1016/S1474-4422(17)30283-1 |
| format | Article |
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Ongoing multicentre trials that incorporate motor biomarkers could help to bring their use into routine clinical practice.</description><identifier>ISSN: 1474-4422</identifier><identifier>EISSN: 1474-4465</identifier><identifier>DOI: 10.1016/S1474-4422(17)30283-1</identifier><identifier>PMID: 28920888</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biomarkers ; Clinical trials ; Electroencephalography ; Evoked Potentials - physiology ; Humans ; Motor Disorders - etiology ; Motor Disorders - physiopathology ; Neurobiology ; Neuroimaging ; Patients ; Recovery (Medical) ; Recovery of Function - physiology ; Rehabilitation ; Stroke ; Stroke - complications ; Stroke - physiopathology ; Stroke Rehabilitation ; Structure-function relationships ; Studies</subject><ispartof>Lancet neurology, 2017-10, Vol.16 (10), p.826-836</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. 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Ongoing multicentre trials that incorporate motor biomarkers could help to bring their use into routine clinical practice.</description><subject>Biomarkers</subject><subject>Clinical trials</subject><subject>Electroencephalography</subject><subject>Evoked Potentials - physiology</subject><subject>Humans</subject><subject>Motor Disorders - etiology</subject><subject>Motor Disorders - physiopathology</subject><subject>Neurobiology</subject><subject>Neuroimaging</subject><subject>Patients</subject><subject>Recovery (Medical)</subject><subject>Recovery of Function - physiology</subject><subject>Rehabilitation</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Stroke - physiopathology</subject><subject>Stroke Rehabilitation</subject><subject>Structure-function relationships</subject><subject>Studies</subject><issn>1474-4422</issn><issn>1474-4465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkEtLAzEQgIMotj5-grLgpR5WM0l2s_UipfgCQUE9h2wyC7HtpibbQv-96UMPXjzNMPlmMvMRcgb0CiiU128gpMiFYGwA8pJTVvEc9kh_Vy6L_d-csR45ivGTUgaigkPSY9WQ0aqq-mT0GtA60znfZr7JZr7zIQto_BLDKtNNhyGLXfATvMm0XerWYMxcm9XOz3SYYIgn5KDR04inu3hMPu7v3seP-fPLw9N49JybAqDLJQpuRG0BKqjLgkngw4JzYUoJtuCGslJLWVnd2FLWaTmWginSe8mN1pwfk8F27jz4rwXGTs1cNDid6hb9IioYCgrpJiYTevEH_fSL0KbtNlQJkg7XVLGlTPAxBmzUPLh01EoBVWvHauNYrQUqkGrjWEHqO99NX9QztL9dP1ITcLsFMOlYOgwqGofJnHXJbKesd_988Q3fTIlq</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Stinear, Cathy M</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C2</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Prediction of motor recovery after stroke: advances in biomarkers</title><author>Stinear, Cathy M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-7e43c4bd1181b65271395334c671d53c026a778dafd67b088267bc54c663caa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers</topic><topic>Clinical trials</topic><topic>Electroencephalography</topic><topic>Evoked Potentials - 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| fulltext | fulltext |
| identifier | ISSN: 1474-4422 |
| ispartof | Lancet neurology, 2017-10, Vol.16 (10), p.826-836 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Biomarkers Clinical trials Electroencephalography Evoked Potentials - physiology Humans Motor Disorders - etiology Motor Disorders - physiopathology Neurobiology Neuroimaging Patients Recovery (Medical) Recovery of Function - physiology Rehabilitation Stroke Stroke - complications Stroke - physiopathology Stroke Rehabilitation Structure-function relationships Studies |
| title | Prediction of motor recovery after stroke: advances in biomarkers |
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