Enhanced endothelium epithelial sodium channel signaling prompts left ventricular diastolic dysfunction in obese female mice

Enhanced activation of cell specific mineralocorticoid receptors (MRs) in obesity plays a key role in the development of cardiovascular disease including cardiac diastolic dysfunction as a critical prognosticator. Our previous investigations demonstrated that selective endothelium MR activation prom...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2018-01, Vol.78, p.69-79
Hauptverfasser:	Jia, Guanghong, Habibi, Javad, Aroor, Annayya R., Hill, Michael A., DeMarco, Vincent G., Lee, Li E., Ma, Lixin, Barron, Brady J., Whaley-Connell, Adam, Sowers, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cardiac diastolic dysfunction Diet, Western - adverse effects Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium - metabolism Epithelial sodium channel Epithelial Sodium Channels - metabolism Female Fibrosis - metabolism Fibrosis - physiopathology Heart Ventricles - metabolism Heart Ventricles - physiopathology Inflammation Inflammation - metabolism Inflammation - physiopathology Mice Mice, Inbred C57BL Mice, Obese Myocardium - metabolism Obesity Obesity - metabolism Obesity - physiopathology Oxidative stress Oxidative Stress - physiology Signal Transduction - physiology Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology
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