ADAR RNA editing in human disease; more to it than meets the I

We review the structures and functions of ADARs and their involvements in human diseases. ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and plays a prominent role in promiscuous editing of long dsRNA. Missense mutations that change ADAR1 residues and reduce RN...

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Veröffentlicht in:	Human genetics 2017-09, Vol.136 (9), p.1265-1278
Hauptverfasser:	Gallo, Angela, Vukic, Dragana, Michalík, David, O’Connell, Mary A., Keegan, Liam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Animal models Animals Astrocytoma Autism B cells Biological response modifiers Biomedical and Life Sciences Biomedicine Central nervous system Children Circadian rhythms Double-stranded RNA Encephalitis Epilepsy Excitability Gene Function Glutamate receptors Health aspects Human Genetics Humans Inflammation Interferon Mental Disorders - genetics Mental Disorders - metabolism Metabolic Diseases Mice Mice, Mutant Strains Missense mutation Molecular Medicine Mutation Nervous System Diseases - genetics Nervous System Diseases - metabolism Neuroplasticity Review RNA RNA editing RNA Editing - genetics RNA Processing RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Scaling Seizures Sleep Systemic lupus erythematosus Virus diseases
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