Effects of FCGRIIIa‐158V/F polymorphism on antibody‐dependent cellular cytotoxicity activity of adalimumab

The associations between the efficacy of IgG reagents and the FCGRIIIa‐158V/F polymorphism (rs396991) have been investigated. Although the genotype frequencies in healthy Japanese have been reported, those have varied, as one study reported that the proportions of V/V, V/F, and F/F were 59.1%, 38.6%...

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Veröffentlicht in:	APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2017-12, Vol.125 (12), p.1102-1107
Hauptverfasser:	Kimura, Koji, Kobayashi, Daigo, Hatoyama, Saori, Yamamoto, Mizuki, Takayanagi, Risa, Yamada, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab antibody‐dependent cellular cytotoxicity activity Cytotoxicity Fc receptors FCGRIIIa‐158V/F polymorphism Gene polymorphism Genetic recombination genotype frequency Genotypes Immunoglobulin G Immunotherapy Monoclonal antibodies Polymorphism Reagents Toxicity
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