High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG

High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols; however, its effectiveness for adult ALL has not yet been confirmed in a rigorous manner. We herein conducted a randomized phase III trial comp...

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Veröffentlicht in:	Leukemia 2018-03, Vol.32 (3), p.626-632
Hauptverfasser:	Sakura, T, Hayakawa, F, Sugiura, I, Murayama, T, Imai, K, Usui, N, Fujisawa, S, Yamauchi, T, Yujiri, T, Kakihana, K, Ito, Y, Kanamori, H, Ueda, Y, Miyata, Y, Kurokawa, M, Asou, N, Ohnishi, K, Ohtake, S, Kobayashi, Y, Matsuo, K, Kiyoi, H, Miyazaki, Y, Naoe, T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283/2125 692/308/2779/777 Acute lymphoblastic leukemia Acute lymphocytic leukemia Analysis Cancer Research Clinical trials Critical Care Medicine Dosage and administration Drug therapy Hematology Immunomodulators Intensive Internal Medicine Leukemia Lymphatic leukemia Medicine Medicine & Public Health Methotrexate Oncology original-article Patient outcomes Patients Philadelphia chromosome Remission Survival Therapy Treatment outcome
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