Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections
•Clinicians recommend women receive Tdap vaccine at 27–36weeks of pregnancy for every pregnancy.•Among military mothers Tdap vaccination in pregnancy increased from 0.2% in 2006 to 32.3% in 2013.•Tdap vaccination at 27–36weeks of pregnancy was protective against infant acute respiratory infection.•P...
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| Veröffentlicht in: | Vaccine 2017-10, Vol.35 (42), p.5603-5610 |
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| creator | Khodr, Zeina G. Bukowinski, Anna T. Gumbs, Gia R. Conlin, Ava Marie S. |
| description | •Clinicians recommend women receive Tdap vaccine at 27–36weeks of pregnancy for every pregnancy.•Among military mothers Tdap vaccination in pregnancy increased from 0.2% in 2006 to 32.3% in 2013.•Tdap vaccination at 27–36weeks of pregnancy was protective against infant acute respiratory infection.•Protection was also seen among mothers with prior vaccination, supporting repeat vaccination.•Of the 15 infants with pertussis, only 1 mother received Tdap vaccine in pregnancy (1st trimester).
To protect infants from pertussis infection, the Advisory Committee on Immunization Practices (ACIP) recommends women receive the tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine between 27 and 36weeks of pregnancy. Here, we assessed the association between timing of maternal Tdap vaccination during pregnancy and acute respiratory infection (ARI) in infants |
| doi_str_mv | 10.1016/j.vaccine.2017.08.041 |
| format | Article |
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To protect infants from pertussis infection, the Advisory Committee on Immunization Practices (ACIP) recommends women receive the tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine between 27 and 36weeks of pregnancy. Here, we assessed the association between timing of maternal Tdap vaccination during pregnancy and acute respiratory infection (ARI) in infants <2months of age.
This retrospective cohort study included 99,434 infants born to active duty military women in the Department of Defense Birth and Infant Health Registry from 2006 through 2013. Multivariable log-binomial regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association between maternal Tdap vaccination during pregnancy and infant ARI at <2months of age.
Infants of mothers who received Tdap vaccination during pregnancy vs those who did not were 9% less likely to be diagnosed with an ARI at <2months of age (RR, 0.91; 95% CI, 0.84–0.99), and the risk was 17% lower if vaccination was received between 27 and 36weeks of pregnancy (RR, 0.83; 95% CI, 0.74–0.93). Similar results were observed when comparing mothers who received Tdap vaccination prior to pregnancy in addition to Tdap vaccination between 27 and 36weeks of pregnancy versus mothers who only received vaccination prior to pregnancy (RR, 0.85; 95% CI, 0.74–0.98).
Maternal Tdap vaccination between 27 and 36weeks of pregnancy was consistently protective against infant ARI in the first 2months of life vs no vaccination during pregnancy, regardless of Tdap vaccination prior to pregnancy. Our findings strongly support current ACIP guidelines recommending Tdap vaccination in late pregnancy for every pregnancy.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2017.08.041</identifier><identifier>PMID: 28916245</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Age ; Babies ; Codes ; Confidence intervals ; Diphtheria ; Diphtheria - immunology ; Diphtheria - prevention & control ; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology ; Female ; Humans ; Immunization ; Immunization Schedule ; Infant ; Infant acute respiratory infection ; Infants ; Infections ; Influenza ; Newborn babies ; Pertussis ; Population ; Pregnancy ; Respiratory tract infection ; Respiratory Tract Infections - immunology ; Respiratory Tract Infections - prevention & control ; Retrospective Studies ; Risk ; Risk assessment ; Tdap vaccination ; Tetanus ; Tetanus - immunology ; Tetanus - prevention & control ; Tetanus toxoid, reduced diphtheria toxoid, acellular pertussis ; Timing of Tdap vaccination ; Toxoids - immunology ; Vaccination ; Vaccination - methods ; Vaccinations in pregnancy ; Vaccines ; Whooping cough ; Whooping Cough - immunology ; Whooping Cough - prevention & control ; Womens health</subject><ispartof>Vaccine, 2017-10, Vol.35 (42), p.5603-5610</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 9, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-1338c93318753124aeae82f3f730a326f2775b6bd57fff4373a06bb5160880283</citedby><cites>FETCH-LOGICAL-c440t-1338c93318753124aeae82f3f730a326f2775b6bd57fff4373a06bb5160880283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X17311295$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28916245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khodr, Zeina G.</creatorcontrib><creatorcontrib>Bukowinski, Anna T.</creatorcontrib><creatorcontrib>Gumbs, Gia R.</creatorcontrib><creatorcontrib>Conlin, Ava Marie S.</creatorcontrib><title>Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>•Clinicians recommend women receive Tdap vaccine at 27–36weeks of pregnancy for every pregnancy.•Among military mothers Tdap vaccination in pregnancy increased from 0.2% in 2006 to 32.3% in 2013.•Tdap vaccination at 27–36weeks of pregnancy was protective against infant acute respiratory infection.•Protection was also seen among mothers with prior vaccination, supporting repeat vaccination.•Of the 15 infants with pertussis, only 1 mother received Tdap vaccine in pregnancy (1st trimester).
To protect infants from pertussis infection, the Advisory Committee on Immunization Practices (ACIP) recommends women receive the tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine between 27 and 36weeks of pregnancy. Here, we assessed the association between timing of maternal Tdap vaccination during pregnancy and acute respiratory infection (ARI) in infants <2months of age.
This retrospective cohort study included 99,434 infants born to active duty military women in the Department of Defense Birth and Infant Health Registry from 2006 through 2013. Multivariable log-binomial regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association between maternal Tdap vaccination during pregnancy and infant ARI at <2months of age.
Infants of mothers who received Tdap vaccination during pregnancy vs those who did not were 9% less likely to be diagnosed with an ARI at <2months of age (RR, 0.91; 95% CI, 0.84–0.99), and the risk was 17% lower if vaccination was received between 27 and 36weeks of pregnancy (RR, 0.83; 95% CI, 0.74–0.93). Similar results were observed when comparing mothers who received Tdap vaccination prior to pregnancy in addition to Tdap vaccination between 27 and 36weeks of pregnancy versus mothers who only received vaccination prior to pregnancy (RR, 0.85; 95% CI, 0.74–0.98).
Maternal Tdap vaccination between 27 and 36weeks of pregnancy was consistently protective against infant ARI in the first 2months of life vs no vaccination during pregnancy, regardless of Tdap vaccination prior to pregnancy. Our findings strongly support current ACIP guidelines recommending Tdap vaccination in late pregnancy for every pregnancy.</description><subject>Adult</subject><subject>Age</subject><subject>Babies</subject><subject>Codes</subject><subject>Confidence intervals</subject><subject>Diphtheria</subject><subject>Diphtheria - immunology</subject><subject>Diphtheria - prevention & control</subject><subject>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Infant</subject><subject>Infant acute respiratory infection</subject><subject>Infants</subject><subject>Infections</subject><subject>Influenza</subject><subject>Newborn babies</subject><subject>Pertussis</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Respiratory tract infection</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk assessment</subject><subject>Tdap vaccination</subject><subject>Tetanus</subject><subject>Tetanus - immunology</subject><subject>Tetanus - prevention & control</subject><subject>Tetanus toxoid, reduced diphtheria toxoid, acellular pertussis</subject><subject>Timing of Tdap vaccination</subject><subject>Toxoids - immunology</subject><subject>Vaccination</subject><subject>Vaccination - methods</subject><subject>Vaccinations in pregnancy</subject><subject>Vaccines</subject><subject>Whooping cough</subject><subject>Whooping Cough - immunology</subject><subject>Whooping Cough - prevention & control</subject><subject>Womens health</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9v1DAQxS1ERZfCRwBF4sKhCeM_cbwnVFVQkCr1UiRuluOMWy-7TrDjSnvkm9dhtxy49DSH-c2bmfcIeUehoUDlp03zYKz1ARsGtGtANSDoC7KiquM1a6l6SVbApKgFhZ-n5HVKGwBoOV2_IqdMralkol2RP7c4m5DTeTX46X6-x-jNeWXCUBmL223emlhNGOeckk_VYaWZ_RiqIUcf7qop4l0wwe7_DkUcssVSffpVja7ywZkwF608Y2mmyUczj3G_NNAuOukNOXFmm_DtsZ6RH1-_3F5-q69vrr5fXlzXVgiYa8q5smvOy3_lCSYMGlTMcddxMJxJx7qu7WU_tJ1zTvCOG5B931IJSgFT_Ix8POhOcfydMc1659Pyowk45qTpWhR_JIMF_fAfuhlzDOW6heKgpGqhUO2BsnFMKaLTU_Q7E_eagl4y0ht9zEgvGWlQumRU5t4f1XO_w-Hf1FMoBfh8ALDY8eAx6mQ9huKrj8U0PYz-mRWPWpWmSg</recordid><startdate>20171009</startdate><enddate>20171009</enddate><creator>Khodr, Zeina G.</creator><creator>Bukowinski, Anna T.</creator><creator>Gumbs, Gia R.</creator><creator>Conlin, Ava Marie S.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171009</creationdate><title>Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections</title><author>Khodr, Zeina G. ; Bukowinski, Anna T. ; Gumbs, Gia R. ; Conlin, Ava Marie S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-1338c93318753124aeae82f3f730a326f2775b6bd57fff4373a06bb5160880283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Babies</topic><topic>Codes</topic><topic>Confidence intervals</topic><topic>Diphtheria</topic><topic>Diphtheria - 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khodr, Zeina G.</au><au>Bukowinski, Anna T.</au><au>Gumbs, Gia R.</au><au>Conlin, Ava Marie S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2017-10-09</date><risdate>2017</risdate><volume>35</volume><issue>42</issue><spage>5603</spage><epage>5610</epage><pages>5603-5610</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>•Clinicians recommend women receive Tdap vaccine at 27–36weeks of pregnancy for every pregnancy.•Among military mothers Tdap vaccination in pregnancy increased from 0.2% in 2006 to 32.3% in 2013.•Tdap vaccination at 27–36weeks of pregnancy was protective against infant acute respiratory infection.•Protection was also seen among mothers with prior vaccination, supporting repeat vaccination.•Of the 15 infants with pertussis, only 1 mother received Tdap vaccine in pregnancy (1st trimester).
To protect infants from pertussis infection, the Advisory Committee on Immunization Practices (ACIP) recommends women receive the tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine between 27 and 36weeks of pregnancy. Here, we assessed the association between timing of maternal Tdap vaccination during pregnancy and acute respiratory infection (ARI) in infants <2months of age.
This retrospective cohort study included 99,434 infants born to active duty military women in the Department of Defense Birth and Infant Health Registry from 2006 through 2013. Multivariable log-binomial regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association between maternal Tdap vaccination during pregnancy and infant ARI at <2months of age.
Infants of mothers who received Tdap vaccination during pregnancy vs those who did not were 9% less likely to be diagnosed with an ARI at <2months of age (RR, 0.91; 95% CI, 0.84–0.99), and the risk was 17% lower if vaccination was received between 27 and 36weeks of pregnancy (RR, 0.83; 95% CI, 0.74–0.93). Similar results were observed when comparing mothers who received Tdap vaccination prior to pregnancy in addition to Tdap vaccination between 27 and 36weeks of pregnancy versus mothers who only received vaccination prior to pregnancy (RR, 0.85; 95% CI, 0.74–0.98).
Maternal Tdap vaccination between 27 and 36weeks of pregnancy was consistently protective against infant ARI in the first 2months of life vs no vaccination during pregnancy, regardless of Tdap vaccination prior to pregnancy. Our findings strongly support current ACIP guidelines recommending Tdap vaccination in late pregnancy for every pregnancy.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28916245</pmid><doi>10.1016/j.vaccine.2017.08.041</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Babies Codes Confidence intervals Diphtheria Diphtheria - immunology Diphtheria - prevention & control Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Female Humans Immunization Immunization Schedule Infant Infant acute respiratory infection Infants Infections Influenza Newborn babies Pertussis Population Pregnancy Respiratory tract infection Respiratory Tract Infections - immunology Respiratory Tract Infections - prevention & control Retrospective Studies Risk Risk assessment Tdap vaccination Tetanus Tetanus - immunology Tetanus - prevention & control Tetanus toxoid, reduced diphtheria toxoid, acellular pertussis Timing of Tdap vaccination Toxoids - immunology Vaccination Vaccination - methods Vaccinations in pregnancy Vaccines Whooping cough Whooping Cough - immunology Whooping Cough - prevention & control Womens health |
| title | Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections |
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