A cargo-sorting DNA robot
Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encoding recognition between cargos and their destinati...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2017-09, Vol.357 (6356), p.1112-1112 |
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| creator | Thubagere, Anupama J. Li, Wei Johnson, Robert F. Chen, Zibo Doroudi, Shayan Lee, Yae Lim Izatt, Gregory Wittman, Sarah Srinivas, Niranjan Woods, Damien Winfree, Erik Qian, Lulu |
| description | Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encoding recognition between cargos and their destinations allows for a simple robot design: a single-stranded DNA with one leg and two foot domains for walking, and one arm and one hand domain for picking up and dropping off cargos. The robot explores a two-dimensional testing ground on the surface of DNA origami, picks up multiple cargos of two types that are initially at unordered locations, and delivers them to specified destinations until all molecules are sorted into two distinct piles. The robot is designed to perform a random walk without any energy supply. Exploiting this feature, a single robot can repeatedly sort multiple cargos. Localization on DNA origami allows for distinct cargo-sorting tasks to take place simultaneously in one test tube or for multiple robots to collectively perform the same task. |
| doi_str_mv | 10.1126/science.aan6558 |
| format | Article |
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We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encoding recognition between cargos and their destinations allows for a simple robot design: a single-stranded DNA with one leg and two foot domains for walking, and one arm and one hand domain for picking up and dropping off cargos. The robot explores a two-dimensional testing ground on the surface of DNA origami, picks up multiple cargos of two types that are initially at unordered locations, and delivers them to specified destinations until all molecules are sorted into two distinct piles. The robot is designed to perform a random walk without any energy supply. Exploiting this feature, a single robot can repeatedly sort multiple cargos. Localization on DNA origami allows for distinct cargo-sorting tasks to take place simultaneously in one test tube or for multiple robots to collectively perform the same task.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aan6558</identifier><identifier>PMID: 28912216</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Algorithms ; Antibodies ; Aptamers ; Arm ; Automation ; Cargo ; Chemical communication ; Chemical synthesis ; Chemistry ; Circuits ; Classification ; Conjugation ; Construction materials ; Data processing ; Deoxyribonucleic acid ; Design ; DNA ; DNA, Single-Stranded ; Fluorescence ; Forage ; Information processing ; Localization ; Mathematical models ; Mathematics ; Modular engineering ; Modularity ; Molecular machines ; Multiple robots ; Nanoparticles ; Nanotechnology - instrumentation ; Pheromones ; Position (location) ; Proteins ; Random walk ; RESEARCH ARTICLE SUMMARY ; Robotics ; Robotics - instrumentation ; Robots ; Scaling ; Single-stranded DNA ; Sorting algorithms ; Task complexity ; Walking</subject><ispartof>Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6356), p.1112-1112</ispartof><rights>Copyright © 2017 by the American Association for the Advancement of Science</rights><rights>Copyright © 2017, American Association for the Advancement of Science.</rights><rights>Copyright © 2017, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-70e1ba715dc6c966ab67238fd191a3d80162b6f8e0a80ebeb0c5cf590bca9763</citedby><cites>FETCH-LOGICAL-c454t-70e1ba715dc6c966ab67238fd191a3d80162b6f8e0a80ebeb0c5cf590bca9763</cites><orcidid>0000-0002-5340-8347 ; 0000-0001-8810-9462 ; 0000-0002-5899-7523 ; 0000-0002-7278-679X ; 0000-0003-4115-2409 ; 0000-0001-8916-1932 ; 0000-0002-0602-1406 ; 0000-0001-5961-7775 ; 0000-0002-6453-4023 ; 0000-0003-2990-2895 ; 0000-0002-0638-2690</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26399835$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26399835$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28912216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thubagere, Anupama J.</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Johnson, Robert F.</creatorcontrib><creatorcontrib>Chen, Zibo</creatorcontrib><creatorcontrib>Doroudi, Shayan</creatorcontrib><creatorcontrib>Lee, Yae Lim</creatorcontrib><creatorcontrib>Izatt, Gregory</creatorcontrib><creatorcontrib>Wittman, Sarah</creatorcontrib><creatorcontrib>Srinivas, Niranjan</creatorcontrib><creatorcontrib>Woods, Damien</creatorcontrib><creatorcontrib>Winfree, Erik</creatorcontrib><creatorcontrib>Qian, Lulu</creatorcontrib><title>A cargo-sorting DNA robot</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encoding recognition between cargos and their destinations allows for a simple robot design: a single-stranded DNA with one leg and two foot domains for walking, and one arm and one hand domain for picking up and dropping off cargos. The robot explores a two-dimensional testing ground on the surface of DNA origami, picks up multiple cargos of two types that are initially at unordered locations, and delivers them to specified destinations until all molecules are sorted into two distinct piles. The robot is designed to perform a random walk without any energy supply. Exploiting this feature, a single robot can repeatedly sort multiple cargos. Localization on DNA origami allows for distinct cargo-sorting tasks to take place simultaneously in one test tube or for multiple robots to collectively perform the same task.</description><subject>Algorithms</subject><subject>Antibodies</subject><subject>Aptamers</subject><subject>Arm</subject><subject>Automation</subject><subject>Cargo</subject><subject>Chemical communication</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Circuits</subject><subject>Classification</subject><subject>Conjugation</subject><subject>Construction materials</subject><subject>Data processing</subject><subject>Deoxyribonucleic acid</subject><subject>Design</subject><subject>DNA</subject><subject>DNA, Single-Stranded</subject><subject>Fluorescence</subject><subject>Forage</subject><subject>Information processing</subject><subject>Localization</subject><subject>Mathematical models</subject><subject>Mathematics</subject><subject>Modular engineering</subject><subject>Modularity</subject><subject>Molecular machines</subject><subject>Multiple robots</subject><subject>Nanoparticles</subject><subject>Nanotechnology - instrumentation</subject><subject>Pheromones</subject><subject>Position (location)</subject><subject>Proteins</subject><subject>Random walk</subject><subject>RESEARCH ARTICLE SUMMARY</subject><subject>Robotics</subject><subject>Robotics - instrumentation</subject><subject>Robots</subject><subject>Scaling</subject><subject>Single-stranded DNA</subject><subject>Sorting algorithms</subject><subject>Task complexity</subject><subject>Walking</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0D1PwzAQBmALgWgpzIgBVImFJe3Zjh17jMqnVMHS3bIdp0rVxsVOBv59jRpAYrrhfe50ehG6xjDDmPB5tI1rrZtp3XLGxAkaY5AskwToKRoDUJ4JKNgIXcS4AUiZpOdoRITEhGA-Rjfl1Oqw9ln0oWva9fTxvZwGb3x3ic5qvY3uapgTtHp-Wi1es-XHy9uiXGY2Z3mXFeCw0QVmleVWcq4NLwgVdYUl1rQSgDkxvBYOtABnnAHLbM0kGKtlwekEPRzP7oP_7F3s1K6J1m23unW-jwrLHCAXjLFE7__Rje9Dm55Lqsil5DkTSc2PygYfY3C12odmp8OXwqC-S1NDaWooLW3cDXd7s3PVr_9pKYHbI9jEzoe_nFMpBWX0AMz6cOE</recordid><startdate>20170915</startdate><enddate>20170915</enddate><creator>Thubagere, Anupama J.</creator><creator>Li, Wei</creator><creator>Johnson, Robert F.</creator><creator>Chen, Zibo</creator><creator>Doroudi, Shayan</creator><creator>Lee, Yae Lim</creator><creator>Izatt, Gregory</creator><creator>Wittman, Sarah</creator><creator>Srinivas, Niranjan</creator><creator>Woods, Damien</creator><creator>Winfree, Erik</creator><creator>Qian, Lulu</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5340-8347</orcidid><orcidid>https://orcid.org/0000-0001-8810-9462</orcidid><orcidid>https://orcid.org/0000-0002-5899-7523</orcidid><orcidid>https://orcid.org/0000-0002-7278-679X</orcidid><orcidid>https://orcid.org/0000-0003-4115-2409</orcidid><orcidid>https://orcid.org/0000-0001-8916-1932</orcidid><orcidid>https://orcid.org/0000-0002-0602-1406</orcidid><orcidid>https://orcid.org/0000-0001-5961-7775</orcidid><orcidid>https://orcid.org/0000-0002-6453-4023</orcidid><orcidid>https://orcid.org/0000-0003-2990-2895</orcidid><orcidid>https://orcid.org/0000-0002-0638-2690</orcidid></search><sort><creationdate>20170915</creationdate><title>A cargo-sorting DNA robot</title><author>Thubagere, Anupama J. ; Li, Wei ; Johnson, Robert F. ; Chen, Zibo ; Doroudi, Shayan ; Lee, Yae Lim ; Izatt, Gregory ; Wittman, Sarah ; Srinivas, Niranjan ; Woods, Damien ; Winfree, Erik ; Qian, Lulu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-70e1ba715dc6c966ab67238fd191a3d80162b6f8e0a80ebeb0c5cf590bca9763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Algorithms</topic><topic>Antibodies</topic><topic>Aptamers</topic><topic>Arm</topic><topic>Automation</topic><topic>Cargo</topic><topic>Chemical communication</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Circuits</topic><topic>Classification</topic><topic>Conjugation</topic><topic>Construction materials</topic><topic>Data processing</topic><topic>Deoxyribonucleic acid</topic><topic>Design</topic><topic>DNA</topic><topic>DNA, Single-Stranded</topic><topic>Fluorescence</topic><topic>Forage</topic><topic>Information processing</topic><topic>Localization</topic><topic>Mathematical models</topic><topic>Mathematics</topic><topic>Modular engineering</topic><topic>Modularity</topic><topic>Molecular machines</topic><topic>Multiple robots</topic><topic>Nanoparticles</topic><topic>Nanotechnology - 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Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thubagere, Anupama J.</au><au>Li, Wei</au><au>Johnson, Robert F.</au><au>Chen, Zibo</au><au>Doroudi, Shayan</au><au>Lee, Yae Lim</au><au>Izatt, Gregory</au><au>Wittman, Sarah</au><au>Srinivas, Niranjan</au><au>Woods, Damien</au><au>Winfree, Erik</au><au>Qian, Lulu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A cargo-sorting DNA robot</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2017-09-15</date><risdate>2017</risdate><volume>357</volume><issue>6356</issue><spage>1112</spage><epage>1112</epage><pages>1112-1112</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encoding recognition between cargos and their destinations allows for a simple robot design: a single-stranded DNA with one leg and two foot domains for walking, and one arm and one hand domain for picking up and dropping off cargos. The robot explores a two-dimensional testing ground on the surface of DNA origami, picks up multiple cargos of two types that are initially at unordered locations, and delivers them to specified destinations until all molecules are sorted into two distinct piles. The robot is designed to perform a random walk without any energy supply. Exploiting this feature, a single robot can repeatedly sort multiple cargos. 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| ispartof | Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6356), p.1112-1112 |
| issn | 0036-8075 1095-9203 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Algorithms Antibodies Aptamers Arm Automation Cargo Chemical communication Chemical synthesis Chemistry Circuits Classification Conjugation Construction materials Data processing Deoxyribonucleic acid Design DNA DNA, Single-Stranded Fluorescence Forage Information processing Localization Mathematical models Mathematics Modular engineering Modularity Molecular machines Multiple robots Nanoparticles Nanotechnology - instrumentation Pheromones Position (location) Proteins Random walk RESEARCH ARTICLE SUMMARY Robotics Robotics - instrumentation Robots Scaling Single-stranded DNA Sorting algorithms Task complexity Walking |
| title | A cargo-sorting DNA robot |
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