Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase

Three nitric oxide synthase (NOS) isoforms, eNOS, nNOS and iNOS, generate nitric oxide (NO) crucial to the cardiovascular, nervous and host defense systems, respectively. Development of isoform-selective NOS inhibitors is of considerable therapeutic importance. Crystal structures of nNOS-selective d...

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Veröffentlicht in:	Nature Structural Biology 2004-01, Vol.11 (1), p.54-59
Hauptverfasser:	Poulos, Thomas L, Flinspach, Mack L, Li, Huiying, Jamal, Joumana, Yang, Weiping, Huang, Hui, Hah, Jung-Mi, Gómez-Vidal, José Antonio, Litzinger, Elizabeth A, Silverman, Richard B
Format:	Artikel
Sprache:	eng
Schlagworte:	AMIDES Amides - chemistry Amides - pharmacology Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Catalytic Domain Cattle Crystallography, X-Ray Dipeptides - chemistry Dipeptides - pharmacology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes In Vitro Techniques Inhibitors Life Sciences Membrane Biology Models, Molecular Mutagenesis, Site-Directed NITRIC OXIDE Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - chemistry Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type I Nitric Oxide Synthase Type III PARTICLE ACCELERATORS Physiological aspects Protein Isoforms - chemistry Protein Isoforms - pharmacology Protein Structure Protein Structure, Tertiary Rats Residues STANFORD LINEAR ACCELERATOR CENTER STANFORD SYNCHROTRON RADIATION LABORATORY Static Electricity Structure SYNCHROTRON RADIATION
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