A Unifying Concept for Assessing Toxicological Interactions: Changes in Slope

Robust statistical methods are important to the evaluation of toxicological interactions (i.e., departures from additivity) among chemicals in a mixture. However, different concepts of joint toxic action as applied to the statistical analysis of chemical mixture toxicology data or as used in environ...

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Veröffentlicht in:	Toxicological sciences 2005-12, Vol.88 (2), p.287-297
Hauptverfasser:	Gennings, C., Carter, W. H., Carchman, R. A., Teuschler, L. K., Simmons, J. E., Carney, E. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	additivity Complex Mixtures - toxicity Dose-Response Relationship, Drug Drug Synergism interaction index isobologram Models, Statistical nonadditivity Risk Assessment synergy
Online-Zugang:	Volltext
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