Three Faces of N‑Acetylaspartate: Activator, Substrate, and Inhibitor of Human Aspartoacylase

Hydrolysis of N-acetylaspartate (NAA), one of the most concentrated metabolites in brain, catalyzed by human aspartoacylase (hAsp) shows a remarkable dependence of the reaction rate on substrate concentration. At low NAA concentrations, sigmoidal shape of kinetic curve is observed, followed by typic...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The journal of physical chemistry. B 2017-10, Vol.121 (40), p.9389-9397
Hauptverfasser:	Khrenova, Maria G, Kots, Ekaterina D, Varfolomeev, Sergey D, Lushchekina, Sofya V, Nemukhin, Alexander V
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!