GTRAP3‐18 regulates food intake and body weight by interacting with pro‐opiomelanocortin

Pro‐opiomelanocortin (POMC)‐expressing neurons provide α‐melanocyte‐stimulating hormone (α‐MSH), which stimulates melanocortin 4 receptor to induce hypophagia by AMPK inhibition in the hypothalamus. α‐MSH is produced by POMC cleavage in secretory granules and released. However, it is not known yet w...

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Veröffentlicht in:	The FASEB journal 2018-01, Vol.32 (1), p.330-341
Hauptverfasser:	Aoyama, Koji, Bhadhprasit, Wattanaporn, Watabe, Masahiko, Wang, Fan, Matsumura, Nobuko, Nakaki, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism alpha-MSH - metabolism AMP-Activated Protein Kinases - metabolism Anchors Animals Appetite Blood glucose Blood Glucose - metabolism Body weight Body Weight - physiology Brain Brain - metabolism Carrier Proteins - genetics Carrier Proteins - physiology diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Eating - physiology Endoplasmic reticulum Energy transfer Fluorescence Fluorescence resonance energy transfer Food Food intake Glucose Glucose tolerance Glutamic acid transporter Granular materials Hypophagia Hypothalamus Hypothalamus - metabolism Inhibition Insulin Insulin - blood Leptin Leptin - blood Male Melanocortin Mice Mice, Inbred C57BL Mice, Knockout Models, Biological neuron Neurons obesity Post-transcription Pro-Opiomelanocortin - physiology Proopiomelanocortin Protein transport Proteins Regulatory mechanisms (biology) Rodents Secretory vesicles Signaling Weight Loss
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