Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation
Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance...
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| Veröffentlicht in: | Circulation Journal 2018/04/25, Vol.82(5), pp.1237-1244 |
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| container_title | Circulation Journal |
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| creator | Lin, Yung-Kuo Chen, Yi-Ann Lee, Ting-I Chen, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen |
| description | Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF. |
| doi_str_mv | 10.1253/circj.CJ-17-0242 |
| format | Article |
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AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-17-0242</identifier><identifier>PMID: 28904308</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adult ; Aged ; Aging ; Aging - metabolism ; Aging - pathology ; Animals ; Atria ; Atrial fibrillation ; Atrial Fibrillation - metabolism ; Atrial Fibrillation - pathology ; Atrial Fibrillation - physiopathology ; Atrial Remodeling ; Female ; Heart Atria - metabolism ; Heart Atria - pathology ; Heart Atria - physiopathology ; Humans ; Male ; Middle Aged ; Pulmonary veins ; Rabbits</subject><ispartof>Circulation Journal, 2018/04/25, Vol.82(5), pp.1237-1244</ispartof><rights>2018 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-91d7324d74e3f8204c3d95aef2efcd54390df74a1ec900bd85063317a50e6eda3</citedby><cites>FETCH-LOGICAL-c622t-91d7324d74e3f8204c3d95aef2efcd54390df74a1ec900bd85063317a50e6eda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28904308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yung-Kuo</creatorcontrib><creatorcontrib>Chen, Yi-Ann</creatorcontrib><creatorcontrib>Lee, Ting-I</creatorcontrib><creatorcontrib>Chen, Yao-Chang</creatorcontrib><creatorcontrib>Chen, Shih-Ann</creatorcontrib><creatorcontrib>Chen, Yi-Jen</creatorcontrib><title>Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>Atria</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - metabolism</subject><subject>Atrial Fibrillation - pathology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Remodeling</subject><subject>Female</subject><subject>Heart Atria - metabolism</subject><subject>Heart Atria - pathology</subject><subject>Heart Atria - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulmonary veins</subject><subject>Rabbits</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAUhC0EoqVw54Ry5JLiLYuPVUWBqggJytly7JfUVZZiJwf-PUlb2stbpG9Go0HonuApoRF70tbp7XS-DEkSYsrpBRoTxpOQpxRf7u84FClnI3Tj_RZjKnAkrtGIpgJzhtMxWs0KWxfBe2O6UrXgg3YDwVeX-db1b6BqE6ydLQpwPviEqjFQDrytg1nrrCqDhc2cLXutbepbdJWr0sPdcU_Q9-J5PX8NVx8vb_PZKtQxpW0oiEkY5SbhwPI-KdfMiEhBTiHXJuJMYJMnXBHQAuPMpBGOGSOJijDEYBSboMeD7841Px34VlbWa-hT1NB0XhLB0jQiTMQ9ig-odo33DnK5c7ZS7lcSLIcO5b5DOV9Kksihw17ycHTvsgrMSfBfWg8sDsDWt6qAE6Bca3UJR8eUymgYZ-czsFFOQs3-ANeRh0k</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Lin, Yung-Kuo</creator><creator>Chen, Yi-Ann</creator><creator>Lee, Ting-I</creator><creator>Chen, Yao-Chang</creator><creator>Chen, Shih-Ann</creator><creator>Chen, Yi-Jen</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation</title><author>Lin, Yung-Kuo ; Chen, Yi-Ann ; Lee, Ting-I ; Chen, Yao-Chang ; Chen, Shih-Ann ; Chen, Yi-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-91d7324d74e3f8204c3d95aef2efcd54390df74a1ec900bd85063317a50e6eda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Animals</topic><topic>Atria</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - metabolism</topic><topic>Atrial Fibrillation - pathology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Remodeling</topic><topic>Female</topic><topic>Heart Atria - metabolism</topic><topic>Heart Atria - pathology</topic><topic>Heart Atria - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulmonary veins</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yung-Kuo</creatorcontrib><creatorcontrib>Chen, Yi-Ann</creatorcontrib><creatorcontrib>Lee, Ting-I</creatorcontrib><creatorcontrib>Chen, Yao-Chang</creatorcontrib><creatorcontrib>Chen, Shih-Ann</creatorcontrib><creatorcontrib>Chen, Yi-Jen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yung-Kuo</au><au>Chen, Yi-Ann</au><au>Lee, Ting-I</au><au>Chen, Yao-Chang</au><au>Chen, Shih-Ann</au><au>Chen, Yi-Jen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2018</date><risdate>2018</risdate><volume>82</volume><issue>5</issue><spage>1237</spage><epage>1244</epage><pages>1237-1244</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. 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| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aging Aging - metabolism Aging - pathology Animals Atria Atrial fibrillation Atrial Fibrillation - metabolism Atrial Fibrillation - pathology Atrial Fibrillation - physiopathology Atrial Remodeling Female Heart Atria - metabolism Heart Atria - pathology Heart Atria - physiopathology Humans Male Middle Aged Pulmonary veins Rabbits |
| title | Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation |
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