Cobalt-Catalyzed and Lewis Acid-Assisted Nitrile Hydrogenation to Primary Amines: A Combined Effort

The selective hydrogenation of nitriles to primary amines using a bench-stable cobalt precatalyst under 4 atm of H2 is reported herein. The catalyst precursor was reduced in situ using NaHBEt3, and the resulting Lewis acid formed, BEt3, was found to be integral to the observed catalysis. Mechanistic...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-09, Vol.139 (38), p.13554-13561
Hauptverfasser:	Tokmic, Kenan, Jackson, Bailey J, Salazar, Andrea, Woods, Toby J, Fout, Alison R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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