MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk

O6-methylguanine DNA methyl-transferase (MGMT) is the only known critical gene involved in cellular defense against alkylating agents in the DNA direct reversal repair (DRR) pathway. Three single nucleotide polymorphism (SNP) coding for non-conservative amino acid substitutions have been identified...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-12, Vol.26 (12), p.2131-2137
Hauptverfasser:	Shen, Jing, Terry, Mary Beth, Gammon, Marilie D., Gaudet, Mia M., Teitelbaum, Susan L., Eng, Sybil M., Sagiv, Sharon K., Neugut, Alfred I., Santella, Regina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alkylating agents Antioxidants - metabolism Biological and medical sciences Breast Neoplasms - epidemiology Breast Neoplasms - genetics Breast Neoplasms - metabolism Carcinogenesis, carcinogens and anticarcinogens Case-Control Studies confidence interval Diet Dietary Supplements direct reversal repair DRR Female Fluorescence Fruit Genotype Gynecology. Andrology. Obstetrics Haplotypes - genetics Humans ICR interaction contrast ratio LIBCSP Long Island Breast Cancer Study Project Mammary gland diseases Medical sciences Menopause MGMT Middle Aged New York - epidemiology O-Methylguanine-DNA Methyltransferase - genetics O6-methylguanine DNA methyl-transferase odds ratio Polymorphism, Single Nucleotide Risk Factors Smoking Tobacco, tobacco smoking Toxicology Tumors Vegetables
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