Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) is regulated by CREB transcription factors

Re-evaluation of genomic and cDNA data revealed that the human TPT1 gene coding for the translationally controlled tumor protein (TCTP) consists of at least 4211 base pairs. It is transcribed into two transcripts of about 0.8 and 1.2 kb, which contain the same coding region and 5′-UTR, but differ in...

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Veröffentlicht in:	Gene 2006-10, Vol.380 (2), p.95-103
Hauptverfasser:	Andree, Holger, Thiele, Holger, Fähling, Michael, Schmidt, Irina, Thiele, Bernd-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	(TCTP) translationally controlled tumor protein 5' Flanking Region - genetics Animals Binding Sites Biomarkers, Tumor cAMP Colforsin - pharmacology CREB Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism DNA Footprinting - methods DNA-Binding Proteins - metabolism Dogs Electrophoretic Mobility Shift Assay - methods Gene Expression Regulation Humans Mice Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Nuclear Proteins - metabolism Phorbol Esters - pharmacology Promoter elements Promoter Regions, Genetic Rabbits Rats TPT1 gene Transcription Factor AP-1 - metabolism Transcription Factors - metabolism Transcriptional control Transfection Tumor Cells, Cultured
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