Conditional expression of the mutant Ki-ras super(G12C) allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model

To determine the effects of expression of mutant Ki-ras on lung tumorigenesis, we developed a bitransgenic mouse model that expresses the human Ki-ras super(G12C) allele in alveolar type II and/or Clara cells in a tetracycline-inducible, lung-specific manner. Expression of Ki-ras super(G12C) caused...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-12, Vol.26 (12), p.2196-2206
Hauptverfasser:	Floyd, Heather S, Farnsworth, Charles L, Kock, Nancy D, Mizesko, Melissa C, Little, Joy L, Dance, Stephanie T, Everitt, Jeff, Tichelaar, Jay, Whitsett, Jeffrey A, Miller, Mark Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein
Online-Zugang:	Volltext
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