Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

Safety pharmacology is integral to the non-clinical safety assessment of new chemical entities prior to first administration to humans. The zebrafish is a well established model organism that has been shown to be relevant to the study of human diseases. The potential role of zebrafish in safety phar...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2008-07, Vol.58 (1), p.59-68
Hauptverfasser:	Berghmans, Stéphane, Butler, Paul, Goldsmith, Paul, Waldron, Gareth, Gardner, Iain, Golder, Zoe, Richards, Frances M., Kimber, Gillian, Roach, Alan, Alderton, Wendy, Fleming, Angeleen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac function assessment Danio rerio Drug Evaluation, Preclinical - methods Drug safety assessment Drug-Related Side Effects and Adverse Reactions Freshwater Gastrointestinal Tract - drug effects Gastrointestinal Tract - physiology Gut motility assessment Heart - drug effects Heart - physiology Humans Larva - drug effects Larva - metabolism Models, Animal Pharmaceutical Preparations - metabolism QT prolongation Safety pharmacology Species Specificity Time Factors Toxicity Tests - methods Vision, Ocular - drug effects Vision, Ocular - physiology Visual function assessment Zebrafish - physiology Zebrafish methods
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