FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: Activation is not required for repair of Cr(VI)-induced DSBs

Fanconi anemia (FA) is a rare autosomal recessive disorder characterized by congenital abnormalities, progressive bone marrow failure, and cancer susceptibility. FA cells are hypersensitive to DNA crosslinking agents. FA is a genetically heterogeneous disease with at least 11 complementation groups....

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Veröffentlicht in:	Mutation research 2006-11, Vol.610 (1), p.21-30
Hauptverfasser:	Vilcheck, Susan K., Ceryak, Susan, O’Brien, Travis J., Patierno, Steven R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Carcinogen Cells, Cultured Child Chromium Chromium - pharmacology Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) DNA Damage - drug effects DNA interstrand crosslinks DNA Repair - drug effects Double strand breaks Fanconi anemia Fanconi Anemia - metabolism Fanconi Anemia - pathology Fanconi Anemia Complementation Group D2 Protein - metabolism Fanconi Anemia Complementation Group Proteins - metabolism Flow Cytometry Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotoxin H2AX Histones - metabolism Homologous recombination Human lung cells Humans Male Medical genetics Medical sciences S Phase - drug effects Toxicology Ubiquitin - metabolism
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