Curcumin alleviates IL‐17A‐mediated p53‐PAI‐1 expression in bleomycin‐induced alveolar basal epithelial cells

Bleomycin‐mediated inflammatory pathway is known to play an important role in the up regulation of oxidative stress. IL‐17A is a pro‐inflammatory cytokine involved in the modulation of fibrosis. The complex underlying mechanism for the said phenomenon remains unclear. This newly defined investigatio...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-02, Vol.119 (2), p.2222-2230
Hauptverfasser:	Gouda, Mahesh M., Prabhu, Ashwini, Bhandary, Yashodhar P.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells acute lung injury Alveolar Epithelial Cells - cytology Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - metabolism Alveoli Antifibrinolytic agents Apoptosis Apoptosis - drug effects Assaying Bioactive compounds Biocompatibility Biological activity Bleomycin Bleomycin - adverse effects Cascades Cell adhesion & migration Cell migration Cell Movement - drug effects Curcumin Cytokines Cytotoxicity Defects Epithelial cells Fibrin Fibrinolysis Fibrosis Gene Expression Regulation - drug effects Humans IL‐17A Inflammation Inflammatory response Injuries Interleukin-17 - pharmacology Lesions Lung diseases Oxidative stress p53 p53 Protein PAI‐1 Plasminogen Activator Inhibitor 1 - metabolism Polyamide-imides Signaling Toxicity Tumor Suppressor Protein p53 - metabolism
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