PHD3 affects gastric cancer progression by negatively regulating HIF1A

Prolyl hydroxylase 3 (PHD3) is widely accepted as a tumor suppressor; however, the expression of PHD3 in various cancer types remains controversial. The present study aimed to investigate the association between PHD3 expression and the clinicopathological features of gastric cancer using reverse tra...

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Veröffentlicht in:	Molecular medicine reports 2017-11, Vol.16 (5), p.6882-6889
Hauptverfasser:	Xia, Ying-Jie, Jiang, Xiao-Ting, Jiang, Shi-Bin, He, Xu-Jun, Luo, Jun-Gang, Liu, Zheng-Chuang, Wang, Liang, Tao, Hou-Quan, Chen, Jian-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiogenesis Biotechnology Care and treatment Cell Line Cell Movement Development and progression Disease Progression Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Hydroxylases Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a hypoxia-inducible factor-1α Immunohistochemistry Kaplan-Meier Estimate Lymph nodes Male Metastases Metastasis Middle Aged Neoplasm Staging Polymerase chain reaction Prolyl hydroxylase prolyl hydroxylase 3 Prolyl Hydroxylases - chemistry Prolyl Hydroxylases - genetics Prolyl Hydroxylases - metabolism Proteins Real-Time Polymerase Chain Reaction Reverse transcription RNA Interference RNA, Small Interfering - metabolism Stomach cancer Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Tumor cell lines tumor suppressor Tumor suppressor genes Tumors Up-Regulation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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