Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons

Loss-of-function mutations in the progranulin (PGRN) gene are a common cause of familial frontotemporal lobar degeneration (FTLD). This age-related neurodegenerative disorder, characterized by brain atrophy in the frontal and temporal lobes and such typical symptoms as cognitive and memory impairmen...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-11, Vol.363 (2), p.164-175
Hauptverfasser:	Longhena, Francesca, Zaltieri, Michela, Grigoletto, Jessica, Faustini, Gaia, La Via, Luca, Ghidoni, Roberta, Benussi, Luisa, Missale, Cristina, Spano, PierFranco, Bellucci, Arianna
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Base Sequence Cell Survival Cerebral Cortex - cytology Gene Expression Regulation Glycosylation Hippocampus - cytology Intercellular Signaling Peptides and Proteins - chemistry Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Mice Mice, Inbred C57BL Molecular Weight Neuronal Plasticity Neurons - cytology Neurons - metabolism Phosphorylation Receptors, N-Methyl-D-Aspartate - metabolism RNA Interference tau Proteins - metabolism
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