Phosphorylation of epidermal growth factor receptor at serine 1047 in cultured lung alveolar epithelial cells by bradykinin B2 receptor stimulation

Accumulating evidence indicates that epidermal growth factor receptor (EGFR) is desensitized by phosphorylation of serine 1047 (Ser1047). We and other groups have reported that stimulation of a receptor of tumor-necrosis factor α (TNFα) and Toll-like receptor 5 (TLR5) induced the phosphorylation of...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2018-02, Vol.48, p.53-61
Hauptverfasser:	Izumi, Shunsuke, Higa-Nakamine, Sayomi, Nishi, Hiroyuki, Torihara, Hidetsugu, Uehara, Ayako, Sugahara, Kazuhiro, Kakinohana, Manabu, Yamamoto, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Alveolar Epithelial Cells - metabolism Animals Bradykinin Bradykinin - pharmacology Cell Line Dual-Specificity Phosphatases - genetics DUSP5 Epidermal growth factor receptor ErbB Receptors - metabolism ERK Humans Lung - cytology Lung - metabolism Mice Mitogen-Activated Protein Kinases - metabolism p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptor, Bradykinin B2 - metabolism RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - metabolism
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