Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan
We conducted a congener-specific analysis of non-dioxin-like polychlorinated biphenyls (non-dioxin-like PCBs) in blood collected between July 2002 and July 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which full con...
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| Veröffentlicht in: | Chemosphere (Oxford) 2008-10, Vol.73 (6), p.923-931 |
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| creator | Todaka, Takashi Hori, Tsuguhide Hirakawa, Hironori Kajiwara, Jumboku Yasutake, Daisuke Onozuka, Daisuke Kato, Shizue Sasaki, Seiko Nakajima, Sonomi Saijo, Yasuaki Sata, Fumihiro Kishi, Reiko Iida, Takao Furue, Masutaka |
| description | We conducted a congener-specific analysis of non-dioxin-like polychlorinated biphenyls (non-dioxin-like PCBs) in blood collected between July 2002 and July 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which full congener concentrations of non-dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years, median: 28.0 years) and 94 were multipara (mean: 32.3 years, median: 33.0 years). Among the 197 non-dioxin-like PCB congeners, 58 congeners were identified in the blood of pregnant women. The arithmetic mean total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers in Sapporo City were 42.2–329.3 (mean: 114.5, median: 98.6) and 31.5–258.0 (mean: 100.3, median: 91.4)
ng
g
−1
lipid, respectively. The results show that the contamination of non-dioxin-like PCBs in the blood of women has decreased compared to past levels in other domestic areas, in which the subject age was similar to that in this study. The results of the present study indicate that current levels of non-dioxin-like PCBs in the blood of Japanese women and can be used as baseline data for future temporal trends. The sums of the ratios of the concentrations of hexaCBs and heptaCBs to the total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers were 78.5% and 77.7%, respectively. The hexaCBs ratios in the blood of primiparous and multiparous mothers were 45.4% and 44.7%, respectively. HexaCB-153 among hexaCBs congeners, the most abundant congener in the blood of primiparous and multiparous mothers, contributed approximately 22.0% and 21.8% to the total concentrations of 58 non-dioxin-like PCBs congeners that were measured in the blood, respectively. Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers. With regard to the relationship between the total concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the number of deliveries or the age of primiparous and multifarious mothers, the total levels of these PCB congeners tended to decreases with increases in the number of deliveries and significantly i |
| doi_str_mv | 10.1016/j.chemosphere.2008.06.071 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19382893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0045653508008655</els_id><sourcerecordid>14882169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-799d97e2d6f1a9c5d3151fc005a754d504deebdb25dadf435de89ca90fa36fa93</originalsourceid><addsrcrecordid>eNqNkb2u1DAQRi0E4i4XXgGZAioS7Hid2CWK-NWVKIDacuzxXS-OHewskEfgrUm0K6CDaoo538xoDkJPKKkpoe2LY20OMKYyHSBD3RAiatLWpKN30I6KTla0keIu2hGy51XLGb9CD0o5ErKGubyPrlaIipbRHfrZp3gLEXJVJjDeeYN11GEpvuDkcEyxsj798LEK_gvgKYXFHELKPuoZLB78ekNcQsE-4iGkZLFJIYDZmi6nEVPJ8ZThNuo44-9phLihH_U0pZxw7-flOX6vJx0fontOhwKPLvUafX796lP_trr58OZd__KmMpyxueqktLKDxraOamm4ZZRTZwjhuuN7y8neAgx2aLjV1u0ZtyCk0ZI4zVqnJbtGz85zp5y-nqDMavTFQAg6QjoVRSUTjZDs3-BeiIa220R5Bk1OpWRwasp-1HlRlKhNmDqqv4SpTZgirVqFrdnHlyWnYQT7J3kxtAJPL4AuRgeXdTS-_OYa0nFOmFi5_szB-rtvHrIqxkM0YH1edSib_H-c8wvdTL0l</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14882169</pqid></control><display><type>article</type><title>Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Todaka, Takashi ; Hori, Tsuguhide ; Hirakawa, Hironori ; Kajiwara, Jumboku ; Yasutake, Daisuke ; Onozuka, Daisuke ; Kato, Shizue ; Sasaki, Seiko ; Nakajima, Sonomi ; Saijo, Yasuaki ; Sata, Fumihiro ; Kishi, Reiko ; Iida, Takao ; Furue, Masutaka</creator><creatorcontrib>Todaka, Takashi ; Hori, Tsuguhide ; Hirakawa, Hironori ; Kajiwara, Jumboku ; Yasutake, Daisuke ; Onozuka, Daisuke ; Kato, Shizue ; Sasaki, Seiko ; Nakajima, Sonomi ; Saijo, Yasuaki ; Sata, Fumihiro ; Kishi, Reiko ; Iida, Takao ; Furue, Masutaka</creatorcontrib><description>We conducted a congener-specific analysis of non-dioxin-like polychlorinated biphenyls (non-dioxin-like PCBs) in blood collected between July 2002 and July 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which full congener concentrations of non-dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years, median: 28.0 years) and 94 were multipara (mean: 32.3 years, median: 33.0 years). Among the 197 non-dioxin-like PCB congeners, 58 congeners were identified in the blood of pregnant women. The arithmetic mean total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers in Sapporo City were 42.2–329.3 (mean: 114.5, median: 98.6) and 31.5–258.0 (mean: 100.3, median: 91.4)
ng
g
−1
lipid, respectively. The results show that the contamination of non-dioxin-like PCBs in the blood of women has decreased compared to past levels in other domestic areas, in which the subject age was similar to that in this study. The results of the present study indicate that current levels of non-dioxin-like PCBs in the blood of Japanese women and can be used as baseline data for future temporal trends. The sums of the ratios of the concentrations of hexaCBs and heptaCBs to the total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers were 78.5% and 77.7%, respectively. The hexaCBs ratios in the blood of primiparous and multiparous mothers were 45.4% and 44.7%, respectively. HexaCB-153 among hexaCBs congeners, the most abundant congener in the blood of primiparous and multiparous mothers, contributed approximately 22.0% and 21.8% to the total concentrations of 58 non-dioxin-like PCBs congeners that were measured in the blood, respectively. Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers. With regard to the relationship between the total concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the number of deliveries or the age of primiparous and multifarious mothers, the total levels of these PCB congeners tended to decreases with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total concentrations of these PCB congeners in blood and the age of primiparae and multiparae. The concentrations of hexaCB-153 in the blood of primiparous and multiparous mothers showed a close correlation to the total concentrations of these PCBs, suggesting that hexaCB-153 could be an indicator of total concentrations of non-dioxin-like PCB congeners in the blood of pregnant women.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2008.06.071</identifier><identifier>PMID: 18718631</identifier><identifier>CODEN: CMSHAF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Age Distribution ; Biological and medical sciences ; Congener-specific analysis ; Environmental Monitoring ; Environmental Pollutants - blood ; Environmental Pollutants - chemistry ; Environmental pollutants toxicology ; Female ; General aspects ; Human blood ; Humans ; Japan ; Medical sciences ; Middle Aged ; Parity ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - chemistry ; Pregnancy ; Pregnant women ; Sapporo City ; Toxicology</subject><ispartof>Chemosphere (Oxford), 2008-10, Vol.73 (6), p.923-931</ispartof><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-799d97e2d6f1a9c5d3151fc005a754d504deebdb25dadf435de89ca90fa36fa93</citedby><cites>FETCH-LOGICAL-c533t-799d97e2d6f1a9c5d3151fc005a754d504deebdb25dadf435de89ca90fa36fa93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2008.06.071$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20755038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18718631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todaka, Takashi</creatorcontrib><creatorcontrib>Hori, Tsuguhide</creatorcontrib><creatorcontrib>Hirakawa, Hironori</creatorcontrib><creatorcontrib>Kajiwara, Jumboku</creatorcontrib><creatorcontrib>Yasutake, Daisuke</creatorcontrib><creatorcontrib>Onozuka, Daisuke</creatorcontrib><creatorcontrib>Kato, Shizue</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Nakajima, Sonomi</creatorcontrib><creatorcontrib>Saijo, Yasuaki</creatorcontrib><creatorcontrib>Sata, Fumihiro</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Iida, Takao</creatorcontrib><creatorcontrib>Furue, Masutaka</creatorcontrib><title>Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>We conducted a congener-specific analysis of non-dioxin-like polychlorinated biphenyls (non-dioxin-like PCBs) in blood collected between July 2002 and July 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which full congener concentrations of non-dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years, median: 28.0 years) and 94 were multipara (mean: 32.3 years, median: 33.0 years). Among the 197 non-dioxin-like PCB congeners, 58 congeners were identified in the blood of pregnant women. The arithmetic mean total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers in Sapporo City were 42.2–329.3 (mean: 114.5, median: 98.6) and 31.5–258.0 (mean: 100.3, median: 91.4)
ng
g
−1
lipid, respectively. The results show that the contamination of non-dioxin-like PCBs in the blood of women has decreased compared to past levels in other domestic areas, in which the subject age was similar to that in this study. The results of the present study indicate that current levels of non-dioxin-like PCBs in the blood of Japanese women and can be used as baseline data for future temporal trends. The sums of the ratios of the concentrations of hexaCBs and heptaCBs to the total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers were 78.5% and 77.7%, respectively. The hexaCBs ratios in the blood of primiparous and multiparous mothers were 45.4% and 44.7%, respectively. HexaCB-153 among hexaCBs congeners, the most abundant congener in the blood of primiparous and multiparous mothers, contributed approximately 22.0% and 21.8% to the total concentrations of 58 non-dioxin-like PCBs congeners that were measured in the blood, respectively. Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers. With regard to the relationship between the total concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the number of deliveries or the age of primiparous and multifarious mothers, the total levels of these PCB congeners tended to decreases with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total concentrations of these PCB congeners in blood and the age of primiparae and multiparae. The concentrations of hexaCB-153 in the blood of primiparous and multiparous mothers showed a close correlation to the total concentrations of these PCBs, suggesting that hexaCB-153 could be an indicator of total concentrations of non-dioxin-like PCB congeners in the blood of pregnant women.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Biological and medical sciences</subject><subject>Congener-specific analysis</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - chemistry</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>General aspects</subject><subject>Human blood</subject><subject>Humans</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parity</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - chemistry</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Sapporo City</subject><subject>Toxicology</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkb2u1DAQRi0E4i4XXgGZAioS7Hid2CWK-NWVKIDacuzxXS-OHewskEfgrUm0K6CDaoo538xoDkJPKKkpoe2LY20OMKYyHSBD3RAiatLWpKN30I6KTla0keIu2hGy51XLGb9CD0o5ErKGubyPrlaIipbRHfrZp3gLEXJVJjDeeYN11GEpvuDkcEyxsj798LEK_gvgKYXFHELKPuoZLB78ekNcQsE-4iGkZLFJIYDZmi6nEVPJ8ZThNuo44-9phLihH_U0pZxw7-flOX6vJx0fontOhwKPLvUafX796lP_trr58OZd__KmMpyxueqktLKDxraOamm4ZZRTZwjhuuN7y8neAgx2aLjV1u0ZtyCk0ZI4zVqnJbtGz85zp5y-nqDMavTFQAg6QjoVRSUTjZDs3-BeiIa220R5Bk1OpWRwasp-1HlRlKhNmDqqv4SpTZgirVqFrdnHlyWnYQT7J3kxtAJPL4AuRgeXdTS-_OYa0nFOmFi5_szB-rtvHrIqxkM0YH1edSib_H-c8wvdTL0l</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Todaka, Takashi</creator><creator>Hori, Tsuguhide</creator><creator>Hirakawa, Hironori</creator><creator>Kajiwara, Jumboku</creator><creator>Yasutake, Daisuke</creator><creator>Onozuka, Daisuke</creator><creator>Kato, Shizue</creator><creator>Sasaki, Seiko</creator><creator>Nakajima, Sonomi</creator><creator>Saijo, Yasuaki</creator><creator>Sata, Fumihiro</creator><creator>Kishi, Reiko</creator><creator>Iida, Takao</creator><creator>Furue, Masutaka</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7U7</scope></search><sort><creationdate>20081001</creationdate><title>Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan</title><author>Todaka, Takashi ; Hori, Tsuguhide ; Hirakawa, Hironori ; Kajiwara, Jumboku ; Yasutake, Daisuke ; Onozuka, Daisuke ; Kato, Shizue ; Sasaki, Seiko ; Nakajima, Sonomi ; Saijo, Yasuaki ; Sata, Fumihiro ; Kishi, Reiko ; Iida, Takao ; Furue, Masutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-799d97e2d6f1a9c5d3151fc005a754d504deebdb25dadf435de89ca90fa36fa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Biological and medical sciences</topic><topic>Congener-specific analysis</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - chemistry</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>General aspects</topic><topic>Human blood</topic><topic>Humans</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parity</topic><topic>Polychlorinated biphenyls</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Polychlorinated Biphenyls - chemistry</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Sapporo City</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todaka, Takashi</creatorcontrib><creatorcontrib>Hori, Tsuguhide</creatorcontrib><creatorcontrib>Hirakawa, Hironori</creatorcontrib><creatorcontrib>Kajiwara, Jumboku</creatorcontrib><creatorcontrib>Yasutake, Daisuke</creatorcontrib><creatorcontrib>Onozuka, Daisuke</creatorcontrib><creatorcontrib>Kato, Shizue</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Nakajima, Sonomi</creatorcontrib><creatorcontrib>Saijo, Yasuaki</creatorcontrib><creatorcontrib>Sata, Fumihiro</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Iida, Takao</creatorcontrib><creatorcontrib>Furue, Masutaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todaka, Takashi</au><au>Hori, Tsuguhide</au><au>Hirakawa, Hironori</au><au>Kajiwara, Jumboku</au><au>Yasutake, Daisuke</au><au>Onozuka, Daisuke</au><au>Kato, Shizue</au><au>Sasaki, Seiko</au><au>Nakajima, Sonomi</au><au>Saijo, Yasuaki</au><au>Sata, Fumihiro</au><au>Kishi, Reiko</au><au>Iida, Takao</au><au>Furue, Masutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>73</volume><issue>6</issue><spage>923</spage><epage>931</epage><pages>923-931</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><coden>CMSHAF</coden><abstract>We conducted a congener-specific analysis of non-dioxin-like polychlorinated biphenyls (non-dioxin-like PCBs) in blood collected between July 2002 and July 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which full congener concentrations of non-dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years, median: 28.0 years) and 94 were multipara (mean: 32.3 years, median: 33.0 years). Among the 197 non-dioxin-like PCB congeners, 58 congeners were identified in the blood of pregnant women. The arithmetic mean total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers in Sapporo City were 42.2–329.3 (mean: 114.5, median: 98.6) and 31.5–258.0 (mean: 100.3, median: 91.4)
ng
g
−1
lipid, respectively. The results show that the contamination of non-dioxin-like PCBs in the blood of women has decreased compared to past levels in other domestic areas, in which the subject age was similar to that in this study. The results of the present study indicate that current levels of non-dioxin-like PCBs in the blood of Japanese women and can be used as baseline data for future temporal trends. The sums of the ratios of the concentrations of hexaCBs and heptaCBs to the total concentrations of 58 non-dioxin-like PCB congeners in the blood of primiparous and multiparous mothers were 78.5% and 77.7%, respectively. The hexaCBs ratios in the blood of primiparous and multiparous mothers were 45.4% and 44.7%, respectively. HexaCB-153 among hexaCBs congeners, the most abundant congener in the blood of primiparous and multiparous mothers, contributed approximately 22.0% and 21.8% to the total concentrations of 58 non-dioxin-like PCBs congeners that were measured in the blood, respectively. Among the non-dioxin-like PCB congeners measured in the present study, hexaCB-138, heptaCB-170, heptaCB-180, and heptaCB-182/heptaCB-187 also showed high ratios to total concentrations of 58 non-dioxin-like PCB congeners detected in the blood of primiparous and multiparous mothers. With regard to the relationship between the total concentrations of 58 non-dioxin-like PCB congeners in maternal blood and the number of deliveries or the age of primiparous and multifarious mothers, the total levels of these PCB congeners tended to decreases with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total concentrations of these PCB congeners in blood and the age of primiparae and multiparae. The concentrations of hexaCB-153 in the blood of primiparous and multiparous mothers showed a close correlation to the total concentrations of these PCBs, suggesting that hexaCB-153 could be an indicator of total concentrations of non-dioxin-like PCB congeners in the blood of pregnant women.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>18718631</pmid><doi>10.1016/j.chemosphere.2008.06.071</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0045-6535 |
| ispartof | Chemosphere (Oxford), 2008-10, Vol.73 (6), p.923-931 |
| issn | 0045-6535 1879-1298 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19382893 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adolescent Adult Age Distribution Biological and medical sciences Congener-specific analysis Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - chemistry Environmental pollutants toxicology Female General aspects Human blood Humans Japan Medical sciences Middle Aged Parity Polychlorinated biphenyls Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - chemistry Pregnancy Pregnant women Sapporo City Toxicology |
| title | Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T09%3A52%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Congener-specific%20analysis%20of%20non-dioxin-like%20polychlorinated%20biphenyls%20in%20blood%20collected%20from%20195%20pregnant%20women%20in%20Sapporo%20City,%20Japan&rft.jtitle=Chemosphere%20(Oxford)&rft.au=Todaka,%20Takashi&rft.date=2008-10-01&rft.volume=73&rft.issue=6&rft.spage=923&rft.epage=931&rft.pages=923-931&rft.issn=0045-6535&rft.eissn=1879-1298&rft.coden=CMSHAF&rft_id=info:doi/10.1016/j.chemosphere.2008.06.071&rft_dat=%3Cproquest_cross%3E14882169%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14882169&rft_id=info:pmid/18718631&rft_els_id=S0045653508008655&rfr_iscdi=true |